Category Archives: Uncategorized

QOTD: Al Lewis on Getting Rich Quick

One of the best ways to get rich quick is by getting others to think they can get rich quick. You just round up a herd of TV-tuned sheep and take out the shears.

—Al Lewis

Metabolic Syndrome: A Thumbnail Sketch

metabolic syndrome, low-carb diet, diabetes, prediabetes

He’s at high risk for metabolic syndrome

“Metabolic syndrome” may be a new term for you. It’s a collection of clinical features that are associated with increased future risk of type 2 diabetes and atherosclerotic complications such as heart attack and stroke. One in six Americans has metabolic syndrome. Diagnosis requires at least three of the following five conditions:

  • high blood pressure (130/85 or higher, or using a high blood pressure medication)
  • low HDL cholesterol:  under 40 mg/dl (1.03 mmol/l) in a man, under 50 mg/dl (1.28 mmol/l) in a women (or either sex taking a cholesterol-lowering drug)
  • triglycerides over 150 mg/dl (1.70 mmol/l) (or taking a cholesterol-lowering drug)
  • abdominal fat:  waist circumference 40 inches (102 cm) or greater in a man, 35 inches (89 cm) or greater in a woman
  • fasting blood glucose over 100 mg/dl (5.55 mmol/l)

What To Do About It

Metabolic syndrome and simple excess weight often involve impaired carbohydrate metabolism. Over time, excessive carbohydrate consumption can turn overweight and metabolic syndrome into prediabetes, then type 2 diabetes.  Carbohydrate restriction directly addresses impaired carbohydrate metabolism naturally. When my patients have metabolic syndrome, some of my recommendations are:

  • weight loss, often via a low-carb diet (but most any reasonable diet may also work)
  • carbohydrate-restricted diet if blood sugars or triglycerides are elevated
  • regular exercise, a combination of strength and aerobic training

If these are effective, the patient can often avoid costly drugs and their potential adverse effects.

Ask your doctor what she thinks.

Steve Parker, M.D.

ACE Inhibitors May Slow Rate of Decline in Dementia

Larry Huston has the details. ACE inhibitors are commonly used to treat high blood pressure.

The ACE inhibitors in the study were perindopril, ramipril, trandolapril, captopril, fosinopril, lisinopril, prinivil and monopril.

Would a “Treat Meal” Improve Your Weight Management Efforts?

Melanie Thomassian at Dietriffic thinks so. And maybe not just a treat meal but a treat day, once once a week. I’m sure she’s right, at least for some folks. In my books, I talk about “cheat meals” – same thing as a treat meal.

Visit Melanie’s blog for details.

On the other hand, if you’re seriously addicted to certain fattening foods, you might do better swearing them off permanently. For example, alcoholics should never temp themselves with a drink “just this once.”

Have You Heard of the New Weight-Loss Pill, Contrave?

Weight Maven Beth Mazur summarizes results of the phase III trial needed for FDA approval. Contrave is a combo of naltrexone and bupropion.

Beth’s not very impressed with the drug, and neither am i. 

Instead, check out The Advanced Mediterranean Diet.

Retiring Later May Protect Against Alzheimers Dementia

…according to an article at MedPageToday. Use it or lose it?

Is mTORC1 Modulation the Key To Diseases of Civilization?

Was Hippocrates the dude that said something about “make food your medicine”?

Bodo Melnik has an article in DermatoEndocrinology regarding the dietary causes of acne.  He also comments on the role of Western foods in obesity, cancer, diabetes, high blood pressure, and neurodegenerative disorders.  These are our old friends, the “diseases of civilization.”  Melnik mentions the Paleolithic diet favorably.

Melnik says it’s all tied in with mTORC1: mammalian target of rapamycin complex 1.

A snippet:

These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of industrialized food and fast food distribution of Westernized countries. An attenuation of mTORC1 signaling is only possible by increasing the consumption of vegetables and fruit, the major components of vegan or Paleolithic diets. The dermatologist bears a tremendous responsibility for his young acne patients who should be advised to modify their dietary habits in order to reduce activating stimuli of mTORC1, not only to improve acne but to prevent the harmful and expensive march to other mTORC1-related chronic diseases later in life.

You sciencey types can read the rest.  Our new friend mTOR also seems to be involved with growth of muscle induced by resistance exercise.

h/t Mangan

Darrin Carlson Recommends Basic Measuring Devices for the Neophyte Cook

…at The Guy Can Cook. Volume and weight measuring devices, thermometers, etc. Well worth a read if you’re new to cooking. If you’re trying to lose excess weight and keep it off, you need to be cooking at home more than the average person. Darrin writes: 

It’s easy to romanticize the image of the chef who does every thing by instinct.

He knows just how much ingredients to add, how long to cook it, and the exact moment that it’s done.

But we mere mortals are different, and there’s no need to bash our heads against the wall while we consistently ruin dishes that could have been saved with just a bit of science.

In this context, “science” means measuring devices.

Simvastatin (and Other Statins?) May Block Response to Exercise Training

…according to an article in the Journal of the American College of Cardiology. In addition, mitochondrial content fell by 4.5% over the 12-week course of exercise. Mitochondria are the power plants of our body cells. 

h/t David Mendosa

QOTD: Are You Sure You Don’t Have Anything to Hide?

“The Heritage Foundation recently launched an informational campaign to raise awareness of overprosecution and regulatory overreach, appropriately called “USA vs. You” (www.heritage.org/usavsyou). Heritage reports there are now more than 4,500 federal criminal laws on the books, and a whopping 300,000 federal criminal regulations. Throw in state statutes and local ordinances, and our governments have criminalized everyday life to the point that everyone is breakin’ the law — and subject to egregious abuses of authority.

Take the 2011 case of 11-year-old Virginia resident Skylar Capo. She rescued a baby woodpecker from a cat and brought the bird inside a home improvement store, so it wouldn’t suffer in the heat of her mother’s car. A U.S. Fish and Wildlife agent also was at the store, Heritage reported, and read the riot act to Ms. Capo and her mother for violating the Migratory Bird Treaty Act. The Capos released the bird upon returning home and notified the U.S. Fish and Wildlife Service. Yet that same agent, with a Virginia state trooper as backup, showed up at their house two weeks later to serve notice of a $535 federal fine and possible jail time. Public backlash led to all charges being rescinded.

—Editorial at Las Vegas Review-Journal