Category Archives: Pollution

Chemical Exposures Prove Costly for U.S. & Europe

MPT has the story:

“Illness associated with exposure to endocrine-disrupting chemicals (EDCs) reportedly cost the U.S. economy over $340 billion annually, according to an analysis of data collected in the both the U.S. and the European Union.

Led by Leonardo Trasande, MD, of the NYU School of Medicine, the researchers identified the cost of fifteen diseases and dysfunctions linked with environmental EDC exposure, accounting for over 2% of the U.S.’s GDP, published The Lancet Diabetes & Endocrinology.

“Based on our analyses, stronger regulatory oversight of endocrine disrupting chemicals is needed, not just in Europe, but in the U.S.,” said Trasande in a press release. “This oversight should include not only safety tests on the chemicals’ use in the manufacture of commercial products before the chemicals receive government approval, but also studies of their health impact over time once they are used in consumer products.

“The U.S., according to this analysis, is also paying a much higher cost for these exposures: $340 billion versus $217 billion in the EU, a difference that the authors attribute to a laissez faire approach to regulating EDCs in the U.S.

In a 2015 study also led by Trasande, toxicological and epidemiological data was used to evaluate the strength of the relationships between exposure to various EDCs and a list of disorders. This assessment included various disorders such as loss of IQ points and consequent intellectual disability, ADHD, autism, adult and childhood obesity, adult diabetes, cryptorchidism, testicular cancer, male factor infertility, early cardiovascular mortality due to reduce testosterone, leiomyomas, endometriosis, fibroids, and birth defects.”

Source: Chemical Exposures Prove Costly for U.S. | Medpage Today

Click the link to find ways to reduce your exposure to EDCs.

I doubt my books are a significant source of EDC poisoning.

Endocrine-Disrupting Chemicals: An Area of Growing Concern 

The worrisome chemicals, mostly or entirely man-made, are in the environment, water, food or food packaging. From MNT:

“The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals (EDC-2) was developed “to bridge [the] gap between basic, translational, clinical, and public health knowledge, EDCs,” according to its lead author.

“About 10 years ago, the Endocrine Society began working with a group of scientists and physicians to consider the evidence that EDCs are a significant concern for human health,” Andrea C. Gore, PhD, of the University of Texas Austin, told MedPage Today. “In 2009, I led a group of authors in writing a review paper, which led to the Society’s first Scientific Statement. Five years later, the evidence linking EDCs to chronic endocrine diseases involving reproductive, thyroid, cardiovascular, type 2 diabetes mellitus, obesity, and even hormone-sensitive cancers, had mounted. We wrote EDC-2 to review this evidence based on animal models and epidemiology, and the resulting paper allows us to draw much stronger conclusions about concerns about EDC exposures.”

Source: EDCs: An Area of Growing Concern | Medpage Today

The Endocrine Society is Worried About Environmental Chemicals: You Should Be, Too

See text for mention of pancreatic alpha and beta cells

See text for mention of pancreatic alpha and beta cells

A panel of university-based scientists convened by The Endocrine Society recently reviewed the available literature on health effects of endocrine-disrupting chemicals (aka EDCs). The executive summary is available free online. Some excerpts:

The full Scientific Statement represents a comprehensive review of the literature on seven topics for which there is strong mechanistic, experimental, animal, and epidemiological evidence for endocrine disruption, namely: obesity and diabetes, female reproduction, male reproduction, hormone-sensitive cancers in females, prostate cancer, thyroid, and neurodevelopment and neuroendocrine systems. EDCs such as bisphenol A, phthalates, pesticides, persistent organic pollutants such as polychlorinated biphenyls, polybrominated diethyl ethers, and dioxins were emphasized because these chemicals had the greatest depth and breadth of available information.

*  *  *

Both cellular and animal models demonstrate a role for EDCs in the etiology of obesity and T2D [type 2 diabetes]. For obesity, animal studies show that EDC-induced weight gain depends on the timing of exposure and the age of the animals. Exposures during the perinatal period [the weeks before and after birth] trigger obesity later in life. New results covering a whole range of EDC doses have underscored the importance of nonmonotonic dose-response relationships; some doses induced weight increase, whereas others did not. Furthermore, EDCs elicit obesity by acting directly on white adipose tissue, al- though brain, liver, and even the endocrine pancreas may be direct targets as well.

Regarding T2D, animal studies indicate that some EDCs directly target 􏰁beta and alpha cells in the pancreas, adipocytes, and liver cells and provoke insulin resistance together with hyperinsulinemia. These changes can also be associated with altered levels of adiponectin and leptin— often in the absence of weight gain. This diabetogenic action is also a risk factor for cardiovascular diseases, and hyperinsulinemia can drive diet-induced obesity. Epide- miological studies in humans also point to an association between EDC exposures and obesity and/or T2D; however, because many epidemiological studies are cross-sectional, with diet as an important confounding factor in humans, it is not yet possible to infer causality.

RTWT.

Bix at Fanatic Cook blog says foods of animal origin are the major source of harmful persistent organic pollutants, some of which act as ECDs.

Keep your eyes and ears open for new research reports on this critically important topic.

Steve Parker, M.D.