Tag Archives: Bodo Melnik

Is mTORC1 Modulation the Key To Diseases of Civilization?

Was Hippocrates the dude that said something about “make food your medicine”?

Bodo Melnik has an article in DermatoEndocrinology regarding the dietary causes of acne.  He also comments on the role of Western foods in obesity, cancer, diabetes, high blood pressure, and neurodegenerative disorders.  These are our old friends, the “diseases of civilization.”  Melnik mentions the Paleolithic diet favorably.

Melnik says it’s all tied in with mTORC1: mammalian target of rapamycin complex 1.

A snippet:

These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of industrialized food and fast food distribution of Westernized countries. An attenuation of mTORC1 signaling is only possible by increasing the consumption of vegetables and fruit, the major components of vegan or Paleolithic diets. The dermatologist bears a tremendous responsibility for his young acne patients who should be advised to modify their dietary habits in order to reduce activating stimuli of mTORC1, not only to improve acne but to prevent the harmful and expensive march to other mTORC1-related chronic diseases later in life.

You sciencey types can read the rest.  Our new friend mTOR also seems to be involved with growth of muscle induced by resistance exercise.

h/t Mangan