Time-restricted feeding (TRF), a feasible form of intermittent fasting, has been proven to benefit metabolic health in animal models and humans. TRF restricts the daily feeding window to 3 to 12 h for eating ad libitum, with fasting for the rest of the day. To our knowledge, specific guidance on the appropriate time period for eating during TRF has not yet been promoted. Therefore, the aim of the present review was to summarize the current literature on the effects of TRF with different eating windows in humans and compare their effects on metabolic health–related markers. Early TRF (which restricts food intake during the early period of the day) and delayed TRF (which restricts food intake during the later period of the day) studies have shown that both TRF regimens improve metabolic health in terms of reducing energy intake, decreasing body weight, improving insulin sensitivity, reducing blood pressure, and reducing oxidative stress. Differences between the consequences of early and delayed TRF were found, including differences in changes in blood lipid factors. These preliminary findings may help to provide guidance for choosing suitable eating windows during TRF. Future studies with rigorous designs and direct comparisons between the effects of TRF regimens with different eating windows on metabolic health markers are still needed.
Ilana Mercer reminded me that testosterone levels in men have been falling for the last several decades. It’s unclear why. May be related to pollution, overweight and obesity, or decreased incidence of smoking. Not mentioned by Ilana is the dramatic drop in sperm counts.
It is very possible, even likely, that the feminization of society over the past 20 to 30 years is changing males, body and mind. It is very possible that the subliminal stress involved in sublimating one’s essential nature is producing less manly men.
Consider: When they are not twerking tush with transexuals, today’s tykes are required to hack their way through page-turners like One Dad Two Dads Brown Dad Blue Dads. Boyhood today also means BB guns and “bang-bang you’re dead” are banned.
Boys are hardwired for competition; the contemporary school enforces cooperation. Boys like to stand out. But team-work obsessed, mediocre, mostly female school teachers teach them to fade into the background. Boys thrive in more disciplined, structured learning environments; the American school system is synonymous with letting it all hang out.
Sons are more likely to be raised without male mentors, since moms, in the last few decades, are more inclined to divorce (and get custody), never marry, or bear children out of wedlock. The schools have been emptied of manly men and staffed by feminists, mostly lacking in the Y chromosome. Although boys (and girls) require discipline, the rare disciplinarian risks parent-driven litigation.
Former federal MP [Member of Parliament?] Dr Kerryn Phelps has revealed she and her wife both suffered serious and ongoing injures from Covid vaccines, while suggesting the true rate of adverse events is far higher than acknowledged due to underreporting and “threats” from medical regulators.
In an explosive submission to Parliament’s Long Covid inquiry, the former Australian Medical Association (AMA) president has broken her silence about the “devastating” experience — emerging as the most prominent public health figure in the country to speak up about the taboo subject.
“This is an issue that I have witnessed first-hand with my wife who suffered a severe neurological reaction to her first Pfizer vaccine within minutes, including burning face and gums, paraesethesiae, and numb hands and feet, while under observation by myself, another doctor and a registered nurse at the time of immunisation,” the 65-year-old said.
I’ve run across a number of people who slowly increased their alcohol consumption over months or years, not realizing it was causing or would cause problems for them. Alcohol is dangerous, lethal at times.
From a health standpoint, the generally accepted safe levels of consumption are:
no more than one standard drink per day for women
no more than two standard drinks per day for men
One drink is 5 ounces of wine, 12 ounces of beer, or 1.5 ounces of 80 proof distilled spirits (e.g., vodka, whiskey, gin).
Dry January was conceived in the UK in 2012 or 2014. (A related concept is Sober October.) The idea is simply to abstain from all alcohol for the month of January. The Alcohol Change UK website can help you git ‘er done. Many folks notice that they sleep better, have more energy, lose weight, and save money. There are other potential benefits.
If you think you may have an unhealthy relationship with alcohol, check your CAGE score. It’s quick and easy.
Alternatively, if you make a commitment to a Dry January but can’t do it, you may well have a problem.
U.S Supreme Court Justice Ketanji Brown Jackson in her Senate confirmation hearing had difficulty defining “woman.” IIRC, she she couldn’t do it, saying “I’m not a biologist.” Well, I’m not either. But I do have a BS degree in Zoology from way back in 1977.
Without putting much thought into it, here’s my proposed definition of an adult male or female:
If you’re 18 or older (“adulthood” in the U.S.) and a majority of your body’s cells have XY chromosomes, you’re a man. If not, you’re a woman.
Check out this .gov website for alleged facts on sex chromosomes (X and Y). A snippet:
Variation in the number of sex chromosomes in a cell is quite common. Some men have more than two sex chromosomes in all of their cells (the XXY variation is called the Klinefelter syndrome), and many men lose the Y chromosome from their cells as they age.
“Variation in the number of sex chromosomes in a cell is quite common.” Quite common? Klinefelter syndrome occurs in 1 to 2.5 per 1000 boys and men (0.1 to 0.25 percent). It’s news to me that “many men lose the Y chromosome from their cells as they age.”
If a “man” wants to compete as a “woman” in women’s sports, he/she should have a majority of cells with XX chromosomes. Not all cells, but at least 50.001%
It would have been fascinating to be a fly on the wall in the brainstorming sessions that led to this little treatise. The wording was chosen very carefully, not to say anything false outright, much less admit any errors of the past, but to imply that it was only possible to say these things now.
“As SARS-CoV-2, the virus that causes COVID-19, continues to circulate globally, high levels of vaccine- and infection-induced immunity and the availability of effective treatments and prevention tools have substantially reduced the risk for medically significant COVID-19 illness (severe acute illness and post–COVID-19 conditions) and associated hospitalization and death. These circumstances now allow public health efforts to minimize the individual and societal health impacts of COVID-19 by focusing on sustainable measures to further reduce medically significant illness as well as to minimize strain on the health care system, while reducing barriers to social, educational, and economic activity.“
In English: everyone can pretty much go back to normal. Focus on illness that is medically significant. Stop worrying about positive cases because nothing is going to stop them. Think about the bigger picture of overall social health. End the compulsion. Thank you. It’s only two and a half years late.
Proton Pump Inhibitor drugs (PPIs) greatly reduce the production of acid in the stomach. They revolutionized and improved the treatment of ulcers in the stomach and duodenum. When I started medical practice in 1981, I saw many patients who had required stomach surgery to treat their ulcers. Remember the good ol’ Billroth procedures? Of course you don’t. The first PPI approved for use in the US. was cimetidine (Tagamet) in 1979.
But wait, you say. “Isn’t there a reason we have stomach acid in the first place?” Good question! Because if we reduce stomach acid, it may cause problems. Regardless of what acid contributes to food digestion, it also kills germs in food and water. Germs that may kill us if ignored. Most of us in the developed world would be horrified to drink untreated water out of a lake, stream, river, or spring. But what do you think Homo sapiens did for most our 200,000 years of our existence?
Omeprazole was made over the counter in 2003 but I don’t think these drugs should ever have been made available without prescription. PPIs are powerful drugs that treat heartburn by reducing gastric acid production. This is accomplished by PPI binding to the hydrogen/potassium ATPase enzyme on gastric parietal cells lining the stomach. PPIs do more than block acid. They are associated with an increased risk of congestive heart failure, kidney disease, long bone fractures, and dementia, vitamin B12 deficiency, reviewed here. Regular use of proton pump inhibitors is associated with increased incidence of type two diabetes, about 24% higher compared to non-users of the drug. Proton pump inhibitors are also linked an with increased risk of small intestinal bacterial overgrowth (which is a clue as to why these drugs can be harmful). They also increase the risk of infection by Clostridiales difficile by about 2x.
Most of these individual observational studies are unable to establish causation, but the preponderance of evidence points to PPIs causing harm.
Dr Alcock also found evidence that PPI users who catch COVID-19 have 1.6x increased risk for severe disease and death.
If you’re prescribed a PPI for chronic use, check with your physician to see if you still need it. Occasional use for heartburn shouldn’t be a problem. For chronic heartburn, consider a low-carb diet and stop nocturnal alcohol consumption.