Category Archives: Longevity

Glyphosate: Innocuous or Rampant Killer?

Photo by Mikhail Nilov on Pexels.com

Steven Novella recently reviewed the evidence for and against glyphosate, the weed killer that coats many of our plant foods. His conclusion:

While I personally find the evidence overall supports the safety of glyphosate (I feel a risk-based approach is better than a hazard-based approach, there is a wide margin of safety levels, and the best evidence is negative), there is a lot of data that legitimately can be seen as concerning. There is also the question of industry influence in the research. A study from 2000 showing glyphosate is safe was recently retracted because of undisclosed industry funding. It is therefore no wonder that the public remains confused and divided on the safety of glyphosate. 

As it stands, I think the regulatory agencies are correct in continuing to approve glyphosate. It is likely safe and better than all the alternatives. However, more and better research is always welcome. This is definitely an area where we would benefit from highly rigorous large consensus studies designed to resolve continued scientific disagreement.


I encourage you to do your own research and draw your own conclusions. I’m busy with other things now.

—–Steve Parker, M.D.

Here’s Good News If You Have Diabetes and Macular Degeneration Runs in the Family

Photo of the retina at the back of the eyeball, where macular degeneration occurs

Age-related macular degeneration is the #1 cause of blindness high-income societies. A recent study found that metformin use by type 2 diabetics at least 50 years old reduced the incidence of macular degeneration by ~35% over the course of five years. The authors consider their results preliminary and, as usual, recommend further study.

Macular degeneration can be difficult to reverse or treat once it takes hold. As with many illnesses, prevention is better.

Metformin is among the top drug therapies for type 2 diabetes, but it has many competitors on the rise. If macular degeneration runs in your family, this study suggests it may be a good idea to stick with metformin.

Steve Parker, M.D.

Reflections on Life at 92

Is this real or is she AI-generated? How can she be so articulate? I saw little evidence of editing. Was she reading a teleprompter?

I wonder how I would have reacted to this if I were 40, 50, or 60 years old. I’m 71 now, and it made me tear up at the end, and thereafter for many minutes, thinking about my wife, my life, my children, and the time I have left before I shuffle off this mortal coil.

It may be impossible for most folks under 40 or 50 to think seriously about these issues.

—–Steve Parker, M.D.

PS: I can help you maximize your lifespan and “healthspan.”

Study Links Artificial Sweeteners to Increased Death Risk

Photo by Polina Tankilevitch on Pexels.com

A July 2024 article in the July 31, 2024, Nutrition Journal suggests that artificially sweetened beverage consumption may cause increase risk of death, particularly from cardiovascular disease. From the abstract:

Our systematic review and meta-analysis demonstrated a higher consumption of artificially sweetened beverages in relation to higher risks of all-cause and cardiovascular mortality, whereas no relationship of artificially sweetened beverages with cancer mortality was observed. Compared with the participants in the lowest category of artificially sweetened beverage intakes, those in the highest category had a 13% higher risk of premature death from any cause, and a 26% higher risk of CVD (cardiovascular disease) mortality. Each one additional serving increase in artificially sweetened beverage consumption was associated with 6% and 7% higher risk for all-cause and CVD mortality, respectively. In a dose-response meta-analysis, we also observed a linear association of artificially sweetened beverage consumption with CVD mortality, with a non-linear positive association of artificially sweetened beverages with all-cause mortality. Despite this, substitution of sugary sweetened beverages with artificially sweetened beverages was associated with a lower risk of all-cause and CVD mortality. Various sensitivity analyses and subgroups analyses demonstrated the robustness of the pooled associations. Per NutriGrade, quality of the overall evidence was scored moderate for CVD mortality and all-cause mortality.

Steve Parker, M.D.

Ketogenic Diets Reduce Risk of Death

Many physicians and dietitians have been hesitant to suggest ketogenic diets due to 1) possible increased risk of cardiovascular disease, and 2) unknown effects on overall mortality.

But a study published at Scientific Reports in October 2024 suggests that ketogenic diets reduce overall mortality by 24% with no effect on cardiovascular-related deaths. Click the link to see the full report. I haven’t read it yet. Don’t ask me what “restricted cubic spline function” means!

Steve Parker, M.D.

h/t The Low Carb Diabetic

Evidence for Long-Term Safety of Ketogenic Diets

Many physicians and dietitians have been hesitant to suggest ketogenic diets due to 1) possible increased risk of cardiovascular disease, and 2) unknown effects on overall mortality.

But a study published at Scientific Reports in October 2024 suggests that ketogenic diets reduce overall mortality by 24% without no effect on cardiovascular-related deaths. Click the link to see the full report. I haven’t read it yet. Don’t ask me what “restricted cubic spline function” means!

Steve Parker, M.D.

h/t The Low Carb Diabetic

PS: My Resuscitating U.S. Healthcare: An Insider’s Manifesto for Reform ranks at #153 in Health Policy at Amazon’s Kindle store.

Dick Van Dyke and Old Age

If you’re under 60 this may not mean anything to you but it brought a tear to my eye. Coldplay fans may be interested.

Steve Parker, M. D.

Are Dan Buettner’s “Blue Zone” Longevity Hot Spots Legit?

Photo courtesy of USAID SEA. Original public domain image from Flickr

Not according to this analysis. For more info on the Blue Zones, see my review of Buettner’s book.

Steve Parker, M.D.

Ultra-Processed Foods: Not So Bad After All?

Free cheesecake covered berries image“/ CC0 1.0

We’ve heard or suspected for years that whole foods are healthier for us than processed and ultra-processed foods. But is it true?

The British Medical Journal earlier this year published a study concluding that:

…a higher intake of ultra-processed foods was associated with slightly higher all cause mortality, driven by causes other than cancer and cardiovascular diseases. The associations varied across subgroups of ultra-processed foods, with meat/poultry/seafood based ready-to-eat products showing particularly strong associations with mortality.

You can read the study for yourself free online. Did Big Food (e.g., Archer Daniels Midland, Con-Agra, Monsanto) exert any pressure on the researchers. I dunno.

From the Intro:

Ultra-processed foods are ready-to-eat/heat industrial formulations made mostly or entirely from substances derived from foods, including flavors, colors, texturizers, and other additives, with little if any intact whole food.1Ultra-processed foods, which are typically of low nutritional quality and high energy density, have been dominating the food supply of high income countries, and their consumption is markedly increasing in middle income countries.2 Ultra-processed food consumption accounts for 57% of daily energy intake among adults and 67% among youths in the US according to the National Health and Nutrition Examination Survey (NHANES).34

Ultra-processed foods usually disproportionately contribute added sugars, sodium, saturated fats and trans fats, and refined carbohydrates to the diet together with low fiber.56 As well as having low nutritional quality, ultra-processed foods may contain harmful substances, such as additives and contaminants formed during the processing.

Neurologist Steven Novella wrote a brief post about this study over at Science-Based Medicine. You may also find the comment section there enlightening.

Steve Parker, M.D.

Hospice Nurse Julie McFadden Explains Why She Doesn’t Fear Death

Julie has a YouTube channel about hospice nursing, death, and dying.

But if you want to live as long and healthy as possible, consider the Mediterranean diet!

Steve Parker, M.D.