For patients with established cardiovascular disease, a recent study found that aspirin 81 mg/day was just as effective as 325 mg/day in preventing combined risk of death and hospitalization for heart attack or stroke. Rates of major bleeding were the same regardless of dose.
Steve Parker, M.D.
PS: What else prevents heart attacks and strokes? The Mediterranean diet!
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Posted in Heart Disease, Longevity, Stroke
At JeffreyPrather.com. You have lots of company and many options.
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First, remember that blood pressure is reported as two numbers: systolic and diastolic. E.g., 135/92. The first number is the systolic number. A systolic pressure goal of under 120 mmHg may be better than the traditional goal of under 140, at least if you’re “at increased risk for cardiovascular disease.” The study at hand excluded folks with diabetes or prior stroke.
We randomly assigned 9,361 participants who were at increased risk for cardiovascular disease but did not have diabetes or previous stroke to adhere to an intensive treatment target (systolic blood pressure, <120 mm Hg) or a standard treatment target (systolic blood pressure, <140 mm Hg). The primary outcome was a composite of myocardial infarction, other acute coronary syndromes, stroke, acute decompensated heart failure, or death from cardiovascular causes. Additional primary outcome events occurring through the end of the intervention period (August 20, 2015) were adjudicated after data lock for the primary analysis. We also analyzed post-trial observational follow-up data through July 29, 2016.
RESULTS
At a median of 3.33 years of follow-up, the rate of the primary outcome and all-cause mortality during the trial were significantly lower in the intensive-treatment group than in the standard-treatment group (rate of the primary outcome, 1.77% per year vs. 2.40% per year; hazard ratio, 0.73; 95% confidence interval [CI], 0.63 to 0.86; all-cause mortality, 1.06% per year vs. 1.41% per year; hazard ratio, 0.75; 95% CI, 0.61 to 0.92). Serious adverse events of hypotension, electrolyte abnormalities, acute kidney injury or failure, and syncope were significantly more frequent in the intensive-treatment group. When trial and post-trial follow-up data were combined (3.88 years in total), similar patterns were found for treatment benefit and adverse events; however, rates of heart failure no longer differed between the groups.
Steve Parker, M.D.
PS: Exercise and loss of excess weigh helps control and prevent high blood pressure. Let me help.
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It was a mere four days ago that Joe Biden announced his new plan to fight COVID-19. And it’s working like a charm. He scared that virus and it’s on the run. Way to go, Dear Leader Joe!
Here are the CDC’s daily case numbers since the start of the pandemic:
By my reckoning, the recent downtrend in daily cases started around August 31. Biden announced his new plan on September 9.
Steve Parker, M.D.
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Posted in Coronavirus
From The Epoch Times:
On Thursday evening, President Joe Biden unveiled two executive orders that could mandate vaccinations for the CCP (Chinese Communist Party) virus for millions of working Americans in both the public and private spheres. But absent from these mandates are similar requirements for members of Congress, federal judges, or their staffers.
Biden’s executive orders would unilaterally require vaccination for federal employees, the military, and government contractors. The president also asked Occupational Safety and Health Administration (OSHA) to require that firms with over 100 employees either mandate vaccination or weekly CCP virus tests. In total, these mandates could affect over 100 million American workers, making it one of the widest-reaching vaccine mandates in world history.
Steve Parker, M.D.
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From Ron Unz, who is smarter than you and me:
The widespread doubts about the reality of the official story provided by our government and almost universally promoted by our media has severely diminished popular faith in the credibility of those two crucial institutions, with consequences that are still very apparent in today’s highest profile issues.
Over the years, diligent researchers and courageous journalists have largely demolished the original narrative of those events, and have made a strong, perhaps even overwhelming case that the Israeli Mossad together with its American collaborators played the central role. My own reconstruction, substantially relying upon such accumulated evidence, came to such conclusions, and I am therefore republishing it….
I recommend that you RTWT.
Before it’s disappeared by TPTB.
Steve Parker, M.D.
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A few days hence, the Biden administration will be announcing their plan to get the delta variant of COVID-19 under control. But look at the graph of “cases” published by the CDC and you’ll see that delta variant has already peaked. The fed.gov will be taking credit for the decline a couple weeks from now. That’s called leading from the rear.
Also from the CDC, this graph of deaths from March 1, 2020, through Sept 4, 2021. Either the virus is less virulent or we’re learning better how to treat it.
This virus is endemic now. The vaccines will not result in herd immunity because vaccinees catch the virus and spread it to others. That is, vaccinees are not immune. At best, the vaccines still prevent severe disease and death, but I await clinical proof of that. (Israel, Iceland, and Gibralter: share your numbers!) Expect another viral peak in December-January 2021-2022 in the U.S. We may even see a bump after the Labor Day gatherings.
Steve Parker, M.D.
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Posted in Coronavirus
And how we burned in the camps later, thinking: What would things have been like if every Security operative, when he went out at night to make an arrest, had been uncertain whether he would return alive and had to say good-bye to his family? Or if, during periods of mass arrests, as for example in Leningrad, when they arrested a quarter of the entire city, people had not simply sat there in their lairs, paling with terror at every bang of the downstairs door and at every step on the staircase, but had understood they had nothing left to lose and had boldly set up in the downstairs hall an ambush of half a dozen people with axes, hammers, pokers, or whatever else was at hand?… The Organs would very quickly have suffered a shortage of officers and transport and, notwithstanding all of Stalin’s thirst, the cursed machine would have ground to a halt! If…if…We didn’t love freedom enough. And even more – we had no awareness of the real situation…. We purely and simply deserved everything that happened afterward.
-Aleksandr Solzhenitsyn, author of The Gulag Archipelago and other books
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Critics of the use of ivermectin for prevention or treatment for COVID-19 point out potential flaws in the supportive scientific studies. A few of these critiques are:
The non-standard doses of ivermectin are maddening, but understandable. We’re trying to re-purpose a drug that’s already FDA-approved for several indications. Physicians already prescribe numerous drugs where the dose depends on age, weight, renal function, liver function, etc. Big Pharma spends millions of dollars per drug to figure this out when a drug is patent-able. But who’s going to pay for that when the drug is off-patent, like ivermectin? It’d be nice if the CDC or FDA did. We’re already a 18 months into this pandemic.
If ivermectin works at all for COVID-19, the dose for prevention may be different than for treatment. The following are some oral doses I’ve run across, mostly from positive clinical studies. “Kg” means body weight in kilograms. “Mg” means milligrams. If you can’t convert between milligrams and micrograms in your head, do it here. Many ivermectin proponents recommend starting treatment early, especially if there are co-morbidities.
See, doses vary wildly. And don’t ask me if dose should be based on ideal rather than actual body weight.
You probably know that you can often get ivermectin without a prescription. Many countries have decided it’s safe enough to sell over-the-counter.
I’m not recommending ivermectin to you or anybody else. I’m not your doctor. Only your personal physician who knows you, your lab results, your physical exam, and your medical history is in a position to recommend drug therapy.
Steve Parker, M.D.
Updated Jan 20, 2022
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Posted in Coronavirus
For Details, see Ohio Capital Journal on Aug 30, 2021:
A Butler County judge ruled in favor of a woman last week who sought to force a hospital to administer Ivermectin — an animal dewormer that federal regulators have warned against using in COVID-19 patients — to her husband after several weeks in the ICU with the disease.
Butler County Common Pleas Judge Gregory Howard ordered West Chester Hospital, part of the University of Cincinnati network, to treat Jeffrey Smith, 51, with Ivermectin. The order, filed Aug. 23, compels the hospital to provide Smith with 30mg of Ivermectin daily for three weeks.
A number of taxpayer-funded state authorities would not comment on the case. But don’t worry, they won’t miss a paycheck.
The article has a graph showing the number of ivermectin prescriptions dispensed from retail pharmacies in the U.S. from March 2019 to mid-August 2021. A large spike in prescriptions started in early July 2021, leading to almost 90,000 prescriptions in the weak of Aug 13.
Some pharmacists refuse to fill ivermectin prescriptions for COVID-19.
Steve Parker, M.D.
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Advanced Mediterranean Diet 