Tag Archives: adiponectin

Mediterranean Diet Reduces Inflammation in Type 2 Diabetes

 

Santorini, Greek seaside

Santorini, Greek seaside

Markers of inflammation that circulate in our blood are linked to higher rates of type 2 diabetes.

One such marker is C-reactive protein: the higher the CRP, the greater the risk of T2 diabetes.

Another inflammatory marker is adiponectin, a protein secreted by fat cells. Adiponectin levels are inversely related to ongoing inflammation: higher levels of adiponectin indicate lower levels of inflammation. Folks with higher adiponectin levels are at lower risk of type 2 diabetes.

Italian researchers affiliated with the MEDITA clinical trial took 215 men and women with newly diagnosed type 2 diabetes and randomized them to eat either a Mediterranean diet or a low-fat diet. Hemoglobin A1c and inflammatory markers were followed for up to eight years. (I’m not sure, but I think these were relatively mild diabetics from the get-go, probably with HgbA1c under 7%.)

At the end of year one, CRP dropped by 37% and adiponectin rose by 43% in the Mediterranean diet group. In other words, inflammatory markers moved in a healthful direction.

Levels in the low-fat group were unchanged.

For individual Mediterranean dieters who were deemed diet failures (HgbA1c over 7%) at one year, CRP levels were higher and adiponectin levels were lower than their counterparts without diet failure.

Values were also measured two and four years after baseline, but results are not easy to summarize, and I don’t give too much credence to a diet modification purported to last that long. After six to 12 months of a new diet, most folks drift back to their usual way of eating.

Grapes are a time-honored component of the Mediterranean diet

Grapes are a time-honored component of the Mediterranean diet

Action Plan

If you have type 2 diabetes or want to avoid it, consider a Mediterranean-style diet.

Steve Parker, M.D.

PS: Even if you think inflammation is important, you’ll find no shortage of chapters in my books.

Reference: Anti-inflammatory effect of Mediterranean diet in type 2 diabetes is durable: 8-year follow-up of a controlled trial. Diabetes Care, 2016. doi: 10.2337/dc15-2356

Steve Parker MD, Advanced Mediterranean Diet

Two diet books in one

High Adiponectin May Not Protect Against Stroke and Heart Disease After All

I’ve written in the past about adiponectin, a hormone-like protein that may help protect against disease.  Obese folks have less of it.  However, a new study published in Obesity Reviews found no protection against stroke and coronary heart disease (like heart attacks) in people with higher levels of adiponectin.

Read the abstract.