High-Dose Omega-3 Supplement May Lower Alzheimer’s Disease Risk in APOE4 Carriers 

Folks who have inherited a gene called APOE4 have a higher risk for developing Alzheimer’s Dementia compared to those who don’t have the gene. A recent review suggests that supplementing with an omega-3 fatty acid called DHA may help prevent or slow the onset of the dementia.

Cold-water fatty fish are a great source of omega-3 fatty acids, and consumption of these fish seems to protect against dementia. The “dose” is one or two servings a week, for years.

Not everyone can afford fish and some folks don’t like the the taste. So supplements are a consideration for them.

From MPT:

“Giving long-term high doses of docosahexaenoic [DHA] acid to carriers of the apolipoprotein E ε4 (APOE4) allele before the onset of Alzheimer’s disease (AD) dementia may reduce the risk for AD, or delay the onset of symptoms, and should be studied, according to an expert review.

While the review of landmark observational and clinical trials that assessed supplementation with ω-3 fatty acids such as docosahexaenoic acid (DHA),revealed it was not beneficial in symptomatic AD, several observational and clinical trials of ω-3 supplementation in the pre-dementia stage of AD suggested it may slow early memory decline in APOE4 carriers, reported Hussein Yassine, MD, of the Keck School of Medicine at the University of Southern California in Los Angeles, and colleagues.”

Source: High-Dose Omega-3 May Lower AD Risk in APOE4 Carriers | Medpage Today

Steve Parker, M.D.

PS: My books have several easy fish recipes in them.

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