Tag Archives: lorcaserin

Lorcaserin Weight Loss Effects Are Modest

Last year, the FDA approved lorcaserin as a weight-loss drug, the only new drug approved for weight loss in the previous 10 years.  How good is it?  From Obesity Reviews:

“Weight loss of 3.23 kg … and body mass index reduction of 1.16 kg m−2 … was observed compared with placebo in randomized controlled trials of 1 year duration. The use of lorcaserin for 8 and 12 weeks reduced weight of 1.60 kg … and 2.9 kg …, respectively. In comparison to placebo, lorcaserin decreased waist circumference, blood pressure, total cholesterol, low-density lipoprotein-cholesterol and triglycerides, however did not statistically affect heart rate or high-density lipoprotein-cholesterol. Headache, nausea and dizziness were found to be significantly higher in the patients receiving lorcaserin than patients receiving placebo, whereas diarrhoea is no more likely than in patients receiving placebo. In conclusion, lorcaserin achieves modest weight loss and appears to be well tolerated.”

And quess what’s likely to happen when you stop the drug?  

First New Weight-Loss Drug in a Decade: Lorcaserin Hydrochloride

The U.S. Food and Drug Administration today approved lorcaserin hydrochloride as a weight-loss drug, according to MedPage Today.

The drug, to be sold as Belviq in the U.S., is an activator of the serotonin C2 receptor in the brain.  This may reduce food consumption by producing early satiety at mealtime.

According to the FDA’s press release, “the most common side effects of Belviq in non-diabetic patients are headache, dizziness, fatigue, nausea, dry mouth, and constipation, and in diabetic patients are low blood sugar (hypoglycemia), headache, back pain, cough, and fatigue.”

I rarely prescribe weight-loss drugs for my patients.  They’re expensive.  They have side effects.  They’re not very effective.  And when you stop the drug, the fat returns.

Steve Parker, M.D.