The Vampires Are Right: Blood Transfusions from Young People Slow Aging

That’s the claim anyway.

From MIT Technology Review:

“The latest advancement in anti-aging therapies hardly sounds like modern medicine at all. Ambrosia, a startup based in Monterey, California, is launching a clinical trial to inject the blood of young people into just about anyone aged 35 and up—if they’re willing to pay $8,000.

Young-to-old blood transfusions hit the limelight in 2014 when Harvard Stem Cell Institute researcher Amy Wagers discovered that the blood of young mice improved muscle, heart, and brain function in older mice.”

Source: The Next Health Fad? Blood Transfusions from Young People

If this pans out, I bet it can be done for much less than $8,000.

Is Medicare Abolishing the “Two Midnight Rule”?

I was never very good at math, either

I was never very good at math, either

In the U.S., Medicare pays most of the hospital bills for people over 65. If a Medicare patient comes to the emergency department or is otherwise “admitted” for treatment, that hospital stay is considered “observation” if  you can be sent home before the third midnight strikes. Observation status has some important financial implications for the patient; probably more expenses out-of-pocket compared to a regular or full admission.

MedPageToday reported that this “two midnight rule” is being abolished by Medicare.

Most of you are probably already bored by this. I bring this up here because the issue is important to my work as a hospitalist, and I want the public to know what physicians are dealing with as we try to stamp out disease and suffering.

MedPageToday linked to the pertinent announcement by Medicare (aka CMS):

“IPPS Rate Adjustments for Documentation and Coding and Two Midnight Policy:

In the FY 2017 IPPS final rule, CMS is finalizing two adjustments in addition to its annual rate update for inpatient hospital payments.

First, CMS is finalizing the last year of recoupment adjustments required by the American Taxpayer Relief Act of 2012 (ATRA). Section 631 of ATRA requires CMS to recover $11 billion by FY 2017 to fully recoup documentation and coding overpayments related to the transition to the MS-DRGs that began in FY 2008. For FYs 2014, 2015, and 2016, CMS implemented a series of cumulative -0.8 percent adjustments.  For FY 2017, CMS calculates that $5.05 billion of the $11 billion requirement remains to be addressed.  Therefore, CMS is finalizing a -1.5 percent adjustment to complete the statutorily-specified recoupment.

Second, CMS is taking action regarding the -0.2 percent adjustment it implemented in the FY 2014 IPPS/LTCH PPS final rule to account for an estimated increase in Medicare expenditures due to the Two Midnight Policy.  Specifically, in the FY 2014 IPPS/LTCH PPS final rule, CMS estimated that this policy would increase expenditures and accordingly made an adjustment of-0.2 percent to the payment rates.  CMS believes the assumptions underlying the -0.2 percent adjustment were reasonable at the time they were made.  Additionally, CMS does not generally believe it is appropriate in a prospective payment system to retrospectively adjust rates.  However, in light of recent review and the unique circumstances surrounding this adjustment, for FY 2017, CMS is permanently removing this adjustment and also its effects for FYs 2014, 2015, and 2016 by adjusting the FY 2017 payment rates.  This will increase FY 2017 payments by approximately 0.8 percent.”

Source: Hospital Inpatient Prospective Payment System (IPPS) and Long Term Acute Care Hospital (LTCH) Final Rule Policy and Payment Changes for Fiscal Year (FY) 2017

I’m not dumb. I’m not under the influence of drugs or alcohol. But I’ve read that twice and I don’t understand what it has to do with eliminating the “two midnight rule.” I understand very little of it. If you can explain it to me in plain English, please do so.

Steve Parker, M.D.

PS: Medicare is the reason I closed my office-based medical practice and became a hospitalist in 2001

Medical benefits of dental floss unproven 

Another healthy sacred cow bites the dust?

The Washington Post has the story:

“When the federal government issued its latest dietary guidelines this year, the flossing recommendation had been removed, without notice. In a letter to the Associated Press (AP), the government acknowledged the effectiveness of flossing had never been researched, as required.

The AP looked at the most rigorous research conducted over the past decade, focusing on 25 studies that generally compared the use of a toothbrush with the combination of toothbrushes and floss. The findings? The evidence for flossing is “weak, very unreliable,” of “very low” quality, and carries “a moderate to large potential for bias.”

“The majority of available studies fail to demonstrate that flossing is generally effective in plaque removal,” said one review conducted last year. Another 2015 review cites “inconsistent/weak evidence” for flossing and a “lack of efficacy.”

Source: Medical benefits of dental floss unproven – The Washington Post

Hope: A Huge Cost Driver in Medicine 

mountains above the clouds

As a hospitalist, I often end up taking care of patients who are clearly near the end of their lives. Usually I don’t know them well. I don’t know what they’ve been through. I wonder what their regular doctors have been telling them, if anything, about their chances of survival. Too often, I’m the one discussing end of life issues that should have been addressed three months ago.

After reading the article linked below, I have a bit more understanding of the situation. A sample:

“Cancers vary in prognosis. Cancers vary in their response to treatment. This begs the question: In the absence of perfect information, what should the oncologist tell the patient? Should the oncologist reveal the median survival only? If so, why? What normative ethics say only the central tendencies of a distribution be disclosed? Should the oncologist give a whiff of hope that the patient could be an outlier? Should the oncologist mention the short left and not long right tail and stress the imminence of death so that the patient can die gracefully? What is the truth? Is it the median, the long tail of optimism or the short tail of pessimism? If all three are truths which truth should be mentioned first and which truth should be mentioned last?”

Source: Hope: A Huge Cost Driver in Medicine | Medpage Today

Caffeine Restriction Probably Won’t Help Your PMS After All

A lot of medical advice isn’t based on sound science. One example is the common suggestion that women with premenstrual syndrome (PMS) cut back on caffeine.

From AJCN:

“Our findings suggest that caffeine intake is not associated with PMS, and that current recommendations for women to reduce caffeine intake may not help prevent the development of PMS.”

Source: A prospective study of caffeine and coffee intake and premenstrual syndrome

Obese and Have Psoriasis? Weight Loss Reduces Severity

Sure, it’s a small research study and I only have the abstract.

Anyway, a reduced-calorie diet led to loss of 15 kg (33 lb) over 16 weeks. Over the next 48 weeks, dieters only regained 5 kg (11 lb). (But, hey. Diets don’t work, right?)

It’s possible the specific diet itself lead to the psoriasis improvement, but the researchers don’t make that claim in the abstract. They credit the long-term weight loss:

“Long-term weight loss in patients with psoriasis has long-lasting positive effects on the severity of psoriasis.”

Source: Long-term effects of weight reduction on the severity of psoriasis in a cohort derived from a randomized trial: a prospective observational follow-up study

Forty Years of Dietary Advice Was Wrong

Dr. Axel Sigurdsson is a cardiologist who focuses his blogging on cardiovascular disease and lipid disorders. I bet he agrees with me that dietary saturated fat is not the malevolent force we were taught in medical school.

From his blog:

“The [PURE study] suggests that placing carbohydrates at the bottom of the food pyramid based on their effect on blood cholesterol was a mistake. In fact, the data show that replacing dietary carbohydrates with different types of fat may improve lipid profile.

In an interview on Medscape, Dr. Mahshid Dehghan, the principal author of the abstract said: “To summarize our findings, the most adverse effect on blood lipids is from carbohydrates; the most benefit is from consumption of monounsaturated fatty acids; and the effect of saturated and polyunsaturated fatty acids are mixed. I believe this is a big message that we can give because we are confusing people with a low-fat diet and all the complications of total fat consumption, and WHO and AHA all suggest 55% to 60% of energy from carbohydrates.”

Today, most experts agree that diets high in saturated fatty acids or refined carbohydrates are not be recommended for the prevention of heart disease. However, it appears that carbohydrates are likely to cause a greater metabolic damage than saturated fatty acids in the rapidly growing population of people with metabolic abnormalities associated with obesity and insulin resistance.”

Source: High Carbohydrate Intake Worse than High Fat for Blood Lipids

PS: A diet naturally high in monounsaturated fat is one you may have heard of: the Mediterranean diet. The Advanced Mediterranean Diet (2nd Ed.) contains both a low-carb Mediterranean diet and a portion-controlled traditional Mediterranean diet.

Steve Parker MD, Advanced Mediterranean Diet

Two diet books in one

Drinking Coffee Tied to Lower Risk of Suicide 

“Drinking several cups of coffee daily appears to reduce the risk of suicide in men and women by about 50 percent, according to a new study by researchers at the Harvard School of Public Health (HSPH). The study was published online July 2 in The World Journal of Biological Psychiatry.

“Unlike previous investigations, we were able to assess association of consumption of caffeinated and non-caffeinated beverages, and we identify caffeine as the most likely candidate of any putative protective effect of coffee,” said lead researcher Michel Lucas, research fellow in the Department of Nutrition at HSPH.

The authors reviewed data from three large U.S. studies and found that the risk of suicide for adults who drank two to four cups of caffeinated coffee per day was about half that of those who drank decaffeinated coffee or very little or no coffee.”

Source: Coffee drinking tied to lower risk of suicide | Harvard Gazette

Does Dietary Fat Influence Older Brain Function?

MRI scan of brain

MRI scan of brain

The Mediterranean diet has long been linked to lower rates of dementia. Olive oil, a staple of the traditional Mediterranean diet, is rich in monounsaturated fatty acid (oleic acid, specifically). The Mediterranean diet is also relatively low in saturated fatty acid.

From a 2012 study done by Harvard researchers:

“In conclusion, these data suggest that elevated saturated fatty acid intake is related to worse late-life cognitive trajectory, and increased monounsaturated fatty acid intake is related to better cognitive aging. Thus, decreasing saturated fatty acid and increasing monounsaturated fatty acid merit further consideration in promoting healthy cognitive aging, and dietary patterns that incorporate higher intake of “good” fats (e.g., Mediterranean) should be further addressed in cognitive aging research.”

Source: Dietary fat types and 4-year cognitive change in community-dwelling older women

PS: The study at hand involved women, so results may not apply to older men.

Steve Parker MD, Advanced Mediterranean Diet

Two diet books in one

Mark Rippetoe: “Once Again, Terrible Exercise Science Gets Praised by Mainstream Media”

“An important new science article has been making the rounds, with apparently every newspaper and internet news aggregator in the world repeating the message: You don’t have to lift heavy weights to get stronger.I know you read it. Here’s the first place I saw it, and here’s the actual paper.

It’s important because it both seems to confirm what everybody wants to believe, and because it’s actually a pretty good technical study. But it is wrong, because it studies the wrong questions. Nonetheless, you now think that you don’t have to lift heavier weights to get stronger.”

Source: Once Again, Terrible Exercise Science Gets Praised by Mainstream Media | PJ Media