Category Archives: Dementia

Higher HemoblobinA1c Levels Linked to Cognitive Decline Over Time

HgbA1c (hemoglobin A1c) is a blood test that reflects average blood sugar levels over the previous three months. From a 2018 study:

In this community-based population, we observed a significant trend for cognitive decline over a 10 year period among individuals aged ≥50 years with normoglycaemia, prediabetes or diabetes at baseline. Additionally, HbA1c levels were linearly associated with subsequent cognitive decline in memory and executive function (but not orientation) irrespective of diabetes status at baseline.

Source: HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing | SpringerLink

h/t to Jan at The Low-Carb Diabetic

Steve Parker, M.D.

Steve Parker MD, Advanced Mediterranean Diet

Click the pic to purchase at Amazon.com in the U.S.

Gum Disease May Cause or Promote Alzheimer’s Disease

From Medical Xpress:

“Researchers have determined that gum disease (gingivitis) plays a decisive role in whether a person develops Alzheimer´s or not.

“We discovered DNA-based proof that the bacteria causing gingivitis can move from the mouth to the brain,” says researcher Piotr Mydel at Broegelmanns Research Laboratory, Department of Clinical Science, University of Bergen (UiB).

The bacteria produces a protein that destroys nerve cells in the brain, which in turn leads to loss of memory and ultimately, Alzheimer’s.”

Source: Brush your teeth—postpone Alzheimer’s

I take this with a large grain of salt. Click for detailed info on the theory and the Porphyromonas gingivalis bacterium. This organism is the most common bacterium found in the arteries of patients with cardiovascular disease.

Steve Parker, M.D.

Steve Parker MD, Advanced Mediterranean Diet

Click the pic to purchase at Amazon.com in the U.S.

World Health Organization releases guidelines to reduce risk of dementia

Two excerpts:

In guidelines released Tuesday, WHO issued its first recommendations to reduce the risk of dementia globally. They include regular physical exercise, not using tobacco, drinking less alcohol, maintaining healthy blood pressure and eating a healthy diet—particularly a Mediterranean one.

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“The Mediterranean diet is the most extensively studied dietary approach, in general as well as in relation to cognitive function,” the report said. “Several systematic reviews of observational studies have concluded that high adherence to the Mediterranean diet is associated with decreased risk of mild cognitive impairment and Alzheimer’s Disease, but modest adherence is not.”

Source: New global guidelines to reduce risk of dementia released

Steve Parker, M.D.

Steve Parker MD, Advanced Mediterranean Diet

Click the pic to purchase at Amazon.com in the U.S.

Tighter blood pressure control may cut memory loss, even dementia

dementia, memory loss, Mediterranean diet, low-carb diet, glycemic index, dementia memory loss

“Systolic of 140 isn’t good enough anymore.”

Keep your eyes on this development, folks. Potential game-changer. And a boon to Big Pharma. From NBCnews.com…

Lowering blood pressure to recommended levels can prevent dementia and the memory and thinking problems that often show up first [mild cognitive impairment], researchers reported Wednesday.

People whose top blood pressure reading was taken down to 120 were 19 percent less likely to develop mild cognitive impairment, the loss of memory and brain processing power that usually precedes Alzheimer’s, the study found. And they were 15 percent less likely to eventually develop cognitive decline and dementia.

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It may take a few more years before the study conclusively shows whether the risk of Alzheimer’s was actually reduced because of the lower blood pressure,the researchers said.

It’s the first intervention that has been clearly demonstrated to lower rates of mental decline.

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The findings come from a large trial of blood pressure called the Systolic Blood Pressure Intervention Trial, or SPRINT.

It has already found that lowering systolic blood pressure — the top number in a blood pressure reading — to 120 or less can prevent stroke, heart attacks, kidney disease and other problems.

Source: Tight blood pressure control can cut memory loss, study finds

Guess what else helps prevent memory loss and dementia? The Mediterranean Diet.

Steve Parker MD, Advanced Mediterranean Diet

Two diet books in one

Late-life high blood pressure may harm brain

What kind of blood pressures are we talking about here? 147 mmHg systolic versus 134.

“Autopsies on nearly 1,300 older people, including about 640 clergy members, found more signs of damage and one of the hallmarks of Alzheimer’s disease in the brains of those with higher blood pressure than among those with pressure closer to normal, researchers reported Wednesday.”

Source: Late-life high blood pressure may harm the brain, study says – ABC News

Dementia Rates Are Falling In The U.S.

“An important new national study finds that, after adjusting for age, Americans 65 and older are less likely to get dementia than in the past. The report, published in the Journal of the American Medical Assn (JAMA) confirms previous regional studies in the US as well as recent research in Europe. The reasons for this decline in prevalence of the many dementia-related diseases are complicated, but may be related to higher educational levels. Whatever the cause, the news is positive.”

Source: Dementia Rates Are Falling In The U.S.

High-Dose Omega-3 Supplement May Lower Alzheimer’s Disease Risk in APOE4 Carriers 

Folks who have inherited a gene called APOE4 have a higher risk for developing Alzheimer’s Dementia compared to those who don’t have the gene. A recent review suggests that supplementing with an omega-3 fatty acid called DHA may help prevent or slow the onset of the dementia.

Cold-water fatty fish are a great source of omega-3 fatty acids, and consumption of these fish seems to protect against dementia. The “dose” is one or two servings a week, for years.

Not everyone can afford fish and some folks don’t like the the taste. So supplements are a consideration for them.

From MPT:

“Giving long-term high doses of docosahexaenoic [DHA] acid to carriers of the apolipoprotein E ε4 (APOE4) allele before the onset of Alzheimer’s disease (AD) dementia may reduce the risk for AD, or delay the onset of symptoms, and should be studied, according to an expert review.

While the review of landmark observational and clinical trials that assessed supplementation with ω-3 fatty acids such as docosahexaenoic acid (DHA),revealed it was not beneficial in symptomatic AD, several observational and clinical trials of ω-3 supplementation in the pre-dementia stage of AD suggested it may slow early memory decline in APOE4 carriers, reported Hussein Yassine, MD, of the Keck School of Medicine at the University of Southern California in Los Angeles, and colleagues.”

Source: High-Dose Omega-3 May Lower AD Risk in APOE4 Carriers | Medpage Today

Steve Parker, M.D.

PS: My books have several easy fish recipes in them.