Despite “miracle cure” testimonials #hydroxychloroquine and #azithromycin probably do not work against #COVID19 #Coronavirus

Artist’s rendition of Coronavirus

How does he find the time to do it? Dr David Gorski at Science Based Medicine hits another one out of the ballpark:

The COVID-19 pandemic has been a golden opportunity for quackery and antivaccine conspiracy theories. This is not unexpected, given the size and the current lack of specific therapies for the disease other than supportive care and the current death toll. However, there is another assault on evidence- and science-based medicine that doesn’t come from quacks (although quacks have definitely joined in on the attack). Rather, it comes from desperate and/or opportunistic doctors who, either through a terrified imperative to “do something, anything” in the face of dying patients whom they can’t save or from self-aggrandizing doctors like Dr. Mehmet Oz, Didier Raoult, and others, who, drunk with the arrogance of ignorance and loving the attention, promote unproven treatments with no evidence an irresponsible attitude of, “What harm could it do?” (Answer: A lot. The specific drugs, chloroquine and hydroxychloroquine, have toxicities that have been well-known since the 1960s.) Add to that politicians like Donald Trump, full of magical thinking and possessed of a long history of selling snake oil himself, glommed onto these drugs as the solution to the pandemic before clinical trials showed any benefit.

***

I agree with Dr Gorski’s overall assessment:

I’ll conclude by simply saying this. Taken together, the evidence that hydroxychloroquine, chloroquine, or the hydroxychloroquine/azithromycin combination is an effective treatment for COVID-19 is getting weaker with every publication, to the point where I am 95% sure now that they either don’t work or that any benefit they might have will be outweighed by side effects. Could I still be wrong? Sure, and I’d be happy to be wrong given the desperate need for effective treatments against COVID-19. But I don’t think I am. In the end, the hype over these drugs and particularly the rush by doctors on the flimsiest of evidence to make hydroxychloroquine, in essence, a standard of care, have shown just how weak most doctors’ allegiance to evidence-based medicine is and represent one of the most massive failures of EBM that I can recall.

Source: “Miracle cure” testimonials aside, azithromycin and hydroxychloroquine probably do not work against COVID-19 – Science-Based Medicine

Steve Parker, M.D.

PS: In New York, they found obesity linked to severity of COVID-19 illness.  I can help you with that.

Steve Parker MD, Advanced Mediterranean Diet

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2 responses to “Despite “miracle cure” testimonials #hydroxychloroquine and #azithromycin probably do not work against #COVID19 #Coronavirus

  1. I disagree with your regard for Dr. Gorski.
    I find this name calling on his part :
    or from self-aggrandizing doctors like Dr. Mehmet Oz, Didier Raoult, and others, who, drunk with the arrogance of ignorance and loving the attention

    to greatly diminish my regard for the author.
    What basis does he have for those statements?
    It makes his opinion sound like it’s based on— his (?envious?) opinion.

    The studies I have seen are all reporting on hospitalized patients, while the more promising clinical reports were on outpatients; in preventing them from becoming inpatients.
    I suspect its effectiveness is early in the infection, not once it is well established.

    I fault absolutely no physician who prescribed what is a very inocous drug for the vast majority of patients for such a short term course to vulnerable patients when reports out of Italy were of a 8-13% mortality rate.
    Calling for double blind studies of it at that point in time–when we were looking at a collapse of our care system, deaths of frontline providers, and the resulting civil unrest– struck me as utterly ridiculous.

    Criticizing it now, in hindsight–easy to do, doctor.

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