The findings of this systematic review and meta-analysis of randomized controlled trials suggest that Mediterranean-based interventions are associated with reductions in systolic blood pressure, triglycerides, total cholesterol, and LDL-Cholesterol and an increase in HDL-Cholesterol among children and adolescents. These results underscore the importance of promoting healthy eating habits in youths, as these habits may lead to substantially improved cardiometabolic health, even during the early stages of life.
For several decades, a leading theory on the cause of Alzheimer disease is that a toxic protein called beta amyloid builds up in certain parts of the brain, impairing function. If that’s true, the next questions are 1) why does the protein accumulate, and 2) what can be done to prevent it.
From ABC News:
Allegations that part of a key 2006 study of Alzheimer’s disease may have been fabricated have rocked the research community, calling into question the validity of the study’s influential results.
Science magazine said Thursday that it uncovered evidence that images in the much-cited study, published 16 years ago in the journal Nature, may have been doctored.
***
More than $1 billion of government funding, through the National Institutes of Health, has been directed to amyloid-related Alzheimer’s research. While the investigation suggests that studies of Aβ*56 should be opened up to new scrutiny, experts said the entire theory shouldn’t be discredited.
Steve Parker, M.D.
PS: The Mediterranean diet is linked to lower risk of dementia.
The nephron is the microscopic structural and functional unit of the kidney.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited cause of end-stage kidney disease and affects 500,000 Americans. It is characterized by fluid-filled cysts in both kidneys and gradual deterioration of kidney function. By age 70, affected folks constitute as much as 10% of the end-stage kidney disease population.
Autosomal Recessive Polycystic Kidney Disease is much less common but is more severe.
Trust me, you want to maintain normal kidney function if possible. In ADPKD, standard interventions include adequate fluid consumption, dietary sodium restriction, and keeping blood pressure below 120-125/80 mmHg.
Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights themismatch between our Paleolithic-optimized genes and modern diets, which led to the dramatically increased prevalence of CKD in modern societies. In particular, the Standard American Diet (SAD), high in carbohydrates and ultra-processed foods, causes conditions like type 2 diabetes (T2D), chronic inflammation, and hypertension, leading to CKD. Autosomal dominant polycystic kidney disease (ADPKD), a genetic form of CKD, is characterized by progressive renal cystogenesis that leads to renal failure. This review challenges the fatalistic view of ADPKD as solely a genetic disease. We argue that, just like non-genetic CKD, modern dietary practices, lifestyle, and environmental exposures initiate and accelerate ADPKD progression. Evidence shows that carbohydrate overconsumption, hyperglycemia, and insulin resistance significantly impact renal health. Additionally, factors like dehydration, electrolyte imbalances, nephrotoxin exposure, gastrointestinal dysbiosis, and renal microcrystal formation exacerbate ADPKD. Conversely, carbohydrate restriction, ketogenic metabolic therapy (KMT),and antagonizing the lithogenic risk show promise in slowing ADPKD progression. Addressing disease triggers through dietary modifications and lifestyle changes offers a conservative, non-pharmacological strategy for disease modification in ADPKD. This comprehensive review underscores the urgency of integrating diet and lifestyle factors into the clinical management of ADPKD to mitigate disease progression, improve patient outcomes, and offer therapeutic choices that can be implemented worldwide at low or no cost to healthcare payers and patients.
Posted onJuly 22, 2025|Comments Off on Introducing George Mann and His Role in the Diet-Heart Hypothesis
Heart attacks and chest pains are linked to blocked arteries in the heart
It was around 2009 when I was prepared to abandon the time-honored diet-heart hypothesis. I remember wondering if I’d be excommunicated from the medical community, i.e., lose my medical license due heresy. In a nutshell, the diet-heart hypothesis to which I refer was the idea that dietary saturated fat was the clear-cut cause of coronary artery disease and associated angina pectoris, heart attacks, and cardiac deaths.
My re-evaluation of the evidence lead me to create the ketogenic Mediterranean diet, which is in the 2nd edition of my Advanced Mediterranean diet. Search Amazon.com and you’ll find several other subsequent ketogenic Mediterranean diet books; I wonder if any of them cited my work.
Ancel Keys changed the world. He was right about many things—that lifestyle matters, that food affects disease, that public health can’t afford to wait forever. But in boiling heart disease down to a single nutrient, he oversimplified a complex truth. His hypothesis became policy before it was fully proven. And once policy hardens, it resists correction.
George Mann was no savior. His critiques were often bombastic, his tone combative. But beneath the fire was a warning science should have heeded: that premature consensus can blind, that evidence must lead—not politics, not personalities, not the noise of institutional momentum.
I recommend the entire article to you. I suspect AI (artificial intelligence) was utilized, mainly judging from the three pictures. Dr. Sigurdsson has been publishing some great articles recently, and I believe credited AI in some of them, which is OK by me.
All that follows is from Childers. To facilitate readability, I won’t put it in italics like I usually do quotations:
For years, scientists who questioned mRNA safety were told to put up or shut up (“publish or perish”). Well— now they’ve published. And I’ll give you one guess whether or not the conclusions support our long-standing concerns. Today, a new peer-reviewed study published in the International Journal of Innovative Research in Medical Science, blandly titled “View of Association Between COVID-19 Vaccination and Neuropsychiatric Conditions.”
The results, however, were not bland.
In the just-published peer-reviewed study, researchers analyzed over three decades of vaccine injury reports in the U.S. government’s own VAERS database, comparing covid mRNA vaccines to both flu shots and all other vaccines (combined). Using the CDC’s and FDA’s own method for detecting safety problems —called “Proportional Reporting Ratios” or PRRs— they found that reports of serious neuropsychiatric issues like brain fog, psychosis, dementia, and even suicidal behavior were not just higher, but dozens to hundreds of times more frequent after the covid shots.
If you thought people were crazy to take the jab, you might have been onto something.
The safety signal thresholds weren’t just crossed; they were blown out of the water, with some categories showing PRRs over four hundred, far above the FDA’s red-flag threshold of two. The study concluded these signals were sufficiently alarming to warrant immediate attention and further investigation— an understatement as big as the Statue of Liberty.
Among the most alarming findings, the study flagged massive spikes in reports of serious brain-related problems after covid vaccination. Compared to flu shots, reports of brain fog were up over 100-fold, psychosis nearly 80 times higher, and Alzheimer’s-type dementia more than 40 times more frequent. Even more chilling, reports related to suicidal thoughts or behaviors, including suicide attempts and self-harm, showed increases as high as 80-fold. One rare but deadly condition —cerebral venous sinus thrombosis, a type of brain clot— was reported at rates over 400 times higher than with flu vaccines.
These numbers weren’t small deviations— they were sky-high red flags by the FDA’s own data and safety standards.
Posted onJuly 8, 2025|Comments Off on Ketogenic Diets Reduce Risk of Death
Many physicians and dietitians have been hesitant to suggest ketogenic diets due to 1) possible increased risk of cardiovascular disease, and 2) unknown effects on overall mortality.
Advanced Mediterranean Diet 