Well, I don’t know about the best, but the American Academy of Orthopaedic Surgeons has looked at lots of different options and summarized their recommendations about what to try and what to avoid. They considered:
- glucosamine and chondroitin
- hyaluronic acid injections
- platelet rich plasma
- many others
Science-Based Medicine has an at-a-glance review.
Read the rest of the Academy summary.