It’s in a Science Journal, So It Must Be True, Right?

When I was doing my Internal Medicine residency in 1981 to 1984, we held scientific medical journals in great esteem. The New England Journal of Medicine, for instance. It was published once weekly, about a hundred pages IIRC. At the end of the year, I sent my 52 copies off to a bindery to be glued into a hard-cover book format, to be cherished and consulted for years. That book was two or three inches thick. I did that for maybe five consecutive years; I’ve no idea where they are now. Probably in a landfill.

The told us on the first day of medical school, “Half of what we teach you will be obsolete in five years.” So continuing medical education is an imperative. One of many ways to keep learning is to read medical journals.

You may be surprised to learn that I no longer read scientific medical journals very often. How do I keep my medical practices up to date? I work in the hospital side-by-side with surgeons and medical subspecialists (e.g., cardiologists, gastroenterologists). In general, I talk to them and watch what they do. If there is a ground-breaking new diagnostic tool or therapy, I’ll hear about it from them. They’re not in an ivory tower, isolated from patients. They’re in the trenches with me facing sick and hurting patient every day. I still read scientific medical journals, but take them with a nugget of salt.

I’m a science journal skeptic, questioning their reliability, objectivity, and relevance. By far, I’m not the only one. Check out the writings of Dr. Marcia Angell, former editor of New England Journal of Medicine, and Dr. John Ioannidis.

Seemay Chou had this to say about scientific journals:

I’m a scientist. Over the past five years, I’ve experimented with science outside traditional institutes. From this vantage point, one truth has become inescapable. The journal publishing system — the core of how science is currently shared, evaluated, and rewarded — is fundamentally broken. 

Vox Day has excerpted a TLDR from Chou’s article:

It might seem like publishing is a detail. Something that happens at the end of the process, after the real work of science is done. But in truth, publishing defines science.

The currency of value in science has become journal articles. It’s how scientists share and evaluate their work. Funding and career advancement depend on it. This has added to science growing less rigorous, innovative, and impactful over time. This is not a side effect, a conspiracy, or a sudden crisis. It’s an insidious structural feature.

For non-scientists, here’s how journal-based publishing works:

After years of research, scientists submit a narrative of their results to a journal, chosen based on field relevance and prestige. Journals are ranked by “impact factor,” and publishing in high-impact journals can significantly boost careers, visibility, and funding prospects.

Journal submission timing is often dictated by when results yield a “publishable unit” — a well-known term for what meets a journal’s threshold for significance and coherence. Linear, progressive narratives are favored, even if that means reordering the actual chronology or omitting results that don’t fit. This isn’t fraud; it’s selective storytelling aimed at readability and clarity.

Once submitted, an editor either rejects the paper or sends it to a few anonymous peer reviewers — two or three scientists tasked with judging novelty, technical soundness, and importance. Not all reviews are high quality, and not all concerns are addressed before editorial acceptance. Reviews are usually kept private. Scientific disagreements — essential to progress — rarely play out in public view.

If rejected, the paper is re-submitted elsewhere. This loop generally takes 6–12 months or more. Journal submissions and associated data can circulate in private for over a year without contributing to public discussion. When articles are finally accepted for release, journals require an article processing fee that’s often even more expensive if the article is open access. These fees are typically paid for by taxpayer-funded grants or universities.

Several structural features make the system hard to reform:

  • Illusion of truth and finality: Publication is treated as a stamp of approval. Mistakes are rarely corrected. Retractions are stigmatized.
  • Artificial scarcity: Journals want to be first to publish, fueling secrecy and fear of being “scooped.” Also, author credit is distributed through rigid ordering, incentivizing competition over collaboration. In sum, prestige is then prioritized.
  • Insufficient review that doesn’t scale: Three editorially-selected reviewers (who may have conflicts-of-interest) constrain what can be evaluated, which is a growing problem as science becomes increasingly interdisciplinary and cutting edge. The review process is also too slow and manual to keep up with today’s volume of outputs.
  • Narrow formats: Journals often seek splashy, linear stories with novel mechanistic insights. A lot of useful stuff doesn’t make it into public view, e.g. null findings, methods, raw data, untested ideas, true underlying rationale.
  • Incomplete information: Key components of publications, such as data or code, often aren’t shared to allow full review, reuse, and replication. Journals don’t enforce this, even for publications from companies. Their role has become more akin to marketing.
  • Limited feedback loops: Articles and reviews don’t adapt as new data emerges. Reuse and real-world validation aren’t part of the evaluation loop. A single, shaky published result can derail an entire field for decades, as was the case for the Alzheimer’s scandal.

Stack all this together, and the outcome is predictable: a system that delays and warps the scientific process. It was built about a century ago for a different era. As is often the case with legacy systems, each improvement only further entrenches a principally flawed framework.


—–Steve Parker, M.D.

William S. Blau on Deterioration of the Human Gene Pool

Photo by S.Özgül Alagöz on Pexels.com

Counter-Currents published a review of Blau’s recent book, Our Genetic Future: The Unintended Consequences of Overcoming Natural Selection. This thought-provoking and controversial book may explain why lifespans are decreasing in the U.S, cancers are becoming more frequent in younger people, and even the burgeoning “enshitification” of modern life. If you are intelligent and have an open mind, it’s worth checking out the review by Lipton Matthews. (You may be able to figure out a way to read it w/o subscribing.) A sample:

Contemporary developed societies no longer face intense selective pressure from infectious disease. The selective advantage of immune gene variants that defended against lethal infections has vanished while autoimmune risks remain. The incidence of autoinflammatory and autoimmune disorders has increased markedly, affecting seven to nine percent of the population worldwide and ranking among leading causes of death for young and middle-aged women, with rates increasing ten to twenty percent annually over the past thirty years.

Perhaps most alarming is the documented increase in chronic disease burden across developed societies. Nearly half of American adults suffer from at least one chronic condition. Metabolic disorders including obesity, type 2 diabetes, hypertension, and fatty liver disease have increased dramatically. Early onset cancers affecting people younger than fifty are rising across multiple cancer types.

Blau cites research using the Biological State Index correlating reduced selection pressure with increased disease rates across nations. Countries with least opportunity for natural selection show dramatically higher incidences of cancers, dementia, and type 1 diabetes compared to nations where mortality remains higher. For cancers known to be strongly genetically based, incidence rates in the ten countries with least opportunity for mortality selection exceed rates in the ten countries with greatest opportunity by a factor of 5.7. These associations persist even after controlling for factors like gross domestic product, life expectancy, and lifestyle factors.

Blau’s book forces readers to confront truths that contemporary culture finds deeply unsettling. We prefer narratives of inexorable progress where science and technology ultimately solve whatever problems they create. The notion that our greatest medical triumphs may have initiated genetic degradation that will burden descendants for centuries contradicts every comforting story we tell ourselves about human advancement.

—–Steve Parker, M.D.

The Truth About Plastic Detoxification

Scott Gavura over at Science-Based Medicine writes about the desire to detoxify our bodies periodically:

Free pile plastic bottles image“/ CC0 1.0

Headlines about plastic particles being detected in blood, lungs, placentas, and other tissues have been rapidly assimilated into the wellness ecosystem. Microplastics are tiny plastic particles that come from the breakdown of larger plastic pieces. Because microplastics are ubiquitous, persistent and easily dispersed, they are found in water, food and air – and our bodies. While their impact on human health continues to be studied, the message from wellness entrepreneurs has been simplified to: Plastics are accumulating inside you, and are causing you harm.

This is the perfect setting for detox marketing. Much like the Candida detox kits popular 20 years ago, supplements, binders, sauna protocols, and “plastic detox” programs now claim to remove microplastics (instead of yeast) from the body or reduce an individual’s “plastic burden.” Some businesses and clinics offer testing panels that purport to measure retained plastics, despite the absence of validated methods to do so in a clinically meaningful way. Unlike Candida, microplastics are a real environmental and health issue worthy of study. And that’s happening. But, just like older detox trends, a real scientific issue is already being used to justify claims that go far beyond the evidence.

What’s missing from the marketing claims is any evidence that these detox interventions actually work. Detecting microplastics in human tissues does not automatically imply that they can be selectively removed, or that proposed detox strategies meaningfully alter health outcomes. There is no credible evidence that supplements, saunas, chelation-like binders, or dietary protocols can “flush” plastics from the body. The leap to offering a personal detox solution is marketing, not evidence-based medicine.

The microplastics detox narrative we’re seeing also exploiting a familiar (and recurrent) misunderstanding of toxicology: the assumption that detection equals danger, and that identification necessitates purging. In reality, …

He’s justifiably skeptical about microplastics detoxification protocols. The time may come can rid ourselves of this contamination. But it’s not now.

Steve Parker, M.D.

Merry Christmas: Peace On Earth and Goodwill to All Men

From the Holy Bible (NIV), Matthew 22:36-40:

36 “Teacher, which is the greatest commandment in the Law?”

37 Jesus replied: “‘Love the Lord your God with all your heart and with all your soul and with all your mind.’ 38 This is the first and greatest commandment. 39 And the second is like it: ‘Love your neighbor as yourself.’[ 40 All the Law and the Prophets hang on these two commandments.”

Or if you prefer, click for a written account of The Christmas Truce of 1914.

HHS Working to End Insurance Pre-Authorization

I’ll believe it when I see it.

Health insurance pre-authorization, for example, is when your eye specialist recommends removal of your cataracts so you can see again, but your insurance company wants some clerk or administrator to review everything and either agree or disagree with your physician. If disagree, no eye surgery for you. Unless you’re willing to pay entirely out-of-pocket. Mind you, the clerk does not have a medical degree and has never examined you or spoken to you. Isn’t this one of the reasons Luigi Mangione executed that healthcare executive?

From American Greatness:

Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. joined other federal health officials on Monday to promote an initiative to end the practice of healthcare insurance pre-authorization.

Kennedy was joined by Centers for Medicare & Medicaid Services Administrator Mehmet Oz as part of a roundtable discussion with insurers to discuss pledges made by the health insurance industry to streamline and reform the prior authorization process for Medicare Advantage, Medicaid Managed Care and Affordable Care Act Health Insurance Marketplace plans which account for most insured Americans.

The HHS Secretary commented on how when he joined the presidential transition team, he was told that the single most important thing he could do to improve the experience of patients across the nation was to “end the scourge of pre-authorization.”

Of course, the unsurers will argue that pre-authorization is necessary because those greedy doctors are recommending that surgery, MRI scan, specialty consultation, or physical therapy merely out of greed.

Steve Parker, M.D.

Isn’t That Special: Eliquis Costs $700 in Germany But $8,000 in the U.S.

From Karl Denninger, an article titled Enough of this Nonsense:

I’m talking about the basic economic question: Supply, demand and what happens when you allow someone to force another person to pay your bill.

I keep hammering on this and will until people stop running tropes whether out of sincere (but false) belief or some other reason.

Let’s take Eliquis.  Its a common medication and its expensive.  Roughly 3.5 million Americans take this drug and it is one of the most-commonly prescribed for people who have atrial fibrillation.  It appears to be reasonably effective in reducing the risk of strokes and heart attacks in people with that condition.

It is also about $8,000 a year in the United States without insurance and “insurance” forces those who do not have that condition to pay for those who do — including Medicare and Medicaid.

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The common claim is that “if you cut that off those people will die” because they can’t possibly afford the price.

The claim is false.

In Germany the drug costs about $700 a year, so it is ten times as expensive in the United States.


Parker here. I know why Eliquis (apixaban) so much more expensive in the U.S. I wrote all about it in my latest book. Read Denninger for his opinion. (He’s smarter than me but was wrong about his predicted 2024 severe economic contraction. Making predictions is hard, especially when it’s about the future.)

Steve Parker, M.D.

Study Links Artificial Sweeteners to Increased Death Risk

Photo by Polina Tankilevitch on Pexels.com

A July 2024 article in the July 31, 2024, Nutrition Journal suggests that artificially sweetened beverage consumption may cause increase risk of death, particularly from cardiovascular disease. From the abstract:

Our systematic review and meta-analysis demonstrated a higher consumption of artificially sweetened beverages in relation to higher risks of all-cause and cardiovascular mortality, whereas no relationship of artificially sweetened beverages with cancer mortality was observed. Compared with the participants in the lowest category of artificially sweetened beverage intakes, those in the highest category had a 13% higher risk of premature death from any cause, and a 26% higher risk of CVD (cardiovascular disease) mortality. Each one additional serving increase in artificially sweetened beverage consumption was associated with 6% and 7% higher risk for all-cause and CVD mortality, respectively. In a dose-response meta-analysis, we also observed a linear association of artificially sweetened beverage consumption with CVD mortality, with a non-linear positive association of artificially sweetened beverages with all-cause mortality. Despite this, substitution of sugary sweetened beverages with artificially sweetened beverages was associated with a lower risk of all-cause and CVD mortality. Various sensitivity analyses and subgroups analyses demonstrated the robustness of the pooled associations. Per NutriGrade, quality of the overall evidence was scored moderate for CVD mortality and all-cause mortality.

Steve Parker, M.D.

When It Makes Sense to Go Without Health Insurance in the U.S.

The bike repair shop owner in this video is probably looking at one of the Obamacare insurance plans. They want him to pay $4,000 a year, the government is paying the insurer $7,000 yearly, and yet his deductible is $20,000. That means that if he develops a major medical problem or injury, he still has to pay $20,000 out of pocket before insurance pays a penny. Note that he is in his 30s and relatively healthy. He’s seriously thinking about going without insurance. When and if that major medical problem arises, he’ll just go on Medicaid.

He should think about putting money into a Health Savings Account.

One of the reasons I’m still working at age 71 is that my younger wife needs health insurance and we can get it through my employer.

Steve Parker, M.D.

PS: The books I write generate very little $. I’m just trying to help you guys get healthier and avoid the medical-industrial complex.

This Should Be Good

Bowl fragrant popcorn munch on“/ CC0 1.0

Crenshaw accepted the opportunity for a sit-down interview with Shawn Ryan, tentatively scheduled for Jan 2, 2026.

Shawn Ryan should have mentioned that he is not suicidal and that his vehicles are in good working order.

Someone in the comment section quoted Harry Truman: “Show me a man that gets rich by being a politician, and I’ll show you a crook.” That’s a legit idea even if Truman never said it.

Sadly, any major reform of the U.S. healthcare system will depend on federal and state legislators like Dan Crenshaw.

Steve Parker, M.D.

Plastic Poisoning: Hoax or Horror Show?

It’s getting harder for me to ignore microplastics. They contaminate our water, food, soil, oceans, and air. The guy in this video says the average adult brain contains as much invasive plastic as a typical plastic fork (5 grams?). These plastics are said to cause medical problems although I’m not sure of the strength of the evidence. Very few physicians know about this issue. The video speaker below talks about nanoplastics but in my experience “microplastics” is more often used. Something nano would be smaller than micro, a thousand times smaller if we’re using the metric system. Colloquially, nano may just be “quite a bit smaller” than micro. Video about this issue was published at YouTube Dec 3, 2025:

The speaker refers to a scientific article published at Nature Medicine on Feb 3, 2025: Bioaccumulation of microplastics in decedent human brains. Seems to me they should have used “nanoplastics” in the title instead of “microplastics.”

Not only are the microplastics allegedly bad for us, they are linked to “forever chemicals” which may mediate the badness. E.g., BPA-like chemicals (bisphenol A).

Are you worried about microplastics in your body?

Click this link to NRDC (National Resources Defense Council) for ten tips to keep plastic out of your body.

Steve Parker, M.D.

Update on December 15, 2025:

Katie Couric interviewed Dr. Matthew J Campen, one of the authors of the study referenced above and a toxicology professor at the University of New Mexico. He impresses me with the idea that his study’s findings are very preliminary and need verification by other labs, and that the implications for how we live today are not clear by any means. He speculates that the nanoplastics he finds in human tissue samples were ingested as nanoparticles that originated in landfills years ago. Discarded plastic waste deteriorated over time, breaking down to nanoparticles that contaminated groundwater and also ended up in agricultural products. Therefore, he suggests that there is not much individuals can do about avoiding nanoplastics except perhaps limiting meat consumption. Dr Campen notes that cutting down on our use of plastics now is more likely to help those a couple generations hence than to help us. He is highly skeptical about any current remedies that purport to remove nanoplastics from our tissues. Yet he suggests that our bodies may indeed have an intrinsic mechanism to reject (eject?) the particles.

Dr Campen does not impress me as a hair-on-fire bomb-thrower. Couric did and impressive job interviewing him.

I may start referring to freshly discarded plastics as macroplastics.