Proton Pump Inhibitors Linked to Myriad Diseases

I have nothing against Prilosec in particular. It can be very helpful. It’s one of several PPIs on the market.

Proton Pump Inhibitor drugs (PPIs) greatly reduce the production of acid in the stomach. They revolutionized and improved the treatment of ulcers in the stomach and duodenum. When I started medical practice in 1981, I saw many patients who had required stomach surgery to treat their ulcers. Remember the good ol’ Billroth procedures? Of course you don’t. The first PPI approved for use in the US. was cimetidine (Tagamet) in 1979.

But wait, you say. “Isn’t there a reason we have stomach acid in the first place?” Good question! Because if we reduce stomach acid, it may cause problems. Regardless of what acid contributes to food digestion, it also kills germs in food and water. Germs that may kill us if ignored. Most of us in the developed world would be horrified to drink untreated water out of a lake, stream, river, or spring. But what do you think Homo sapiens did for most our 200,000 years of our existence?

From Joe Alcock, M.D.:

Omeprazole was made over the counter in 2003 but I don’t think these drugs should ever have been made available without prescription. PPIs are powerful drugs that treat heartburn by reducing gastric acid production. This is accomplished by PPI binding to the hydrogen/potassium ATPase enzyme on gastric parietal cells lining the stomach. PPIs do more than block acid. They are associated with an increased risk of congestive heart failure, kidney disease, long bone fractures, and dementia, vitamin B12 deficiency, reviewed here. Regular use of proton pump inhibitors is associated with increased incidence of type two diabetes, about 24% higher compared to non-users of the drug. Proton pump inhibitors are also linked an with increased risk of small intestinal bacterial overgrowth (which is a clue as to why these drugs can be harmful). They also increase the risk of infection by Clostridiales difficile by about 2x.

Most of these individual observational studies are unable to establish causation, but the preponderance of evidence points to PPIs causing harm.

Dr Alcock also found evidence that PPI users who catch COVID-19 have 1.6x increased risk for severe disease and death. 

If you’re prescribed a PPI for chronic use, check with your physician to see if you still need it. Occasional use for heartburn shouldn’t be a problem. For chronic heartburn, consider a low-carb diet and stop nocturnal alcohol consumption.

Steve Parker, M.D.

New Weight-Loss Drug: Tirzepatide

Here’s the evidence at New England Journal of Medicine for tirzepatide for weight loss. It is a once-weekly injection. Cost? Unknown to me.

At baseline, the mean body weight was 104.8 kg, the mean BMI was 38.0, and 94.5% of participants had a BMI of 30 or higher. The mean percentage change in weight at week 72 was −15.0% (95% confidence interval [CI], −15.9 to −14.2) with 5-mg weekly doses of tirzepatide, −19.5% (95% CI, −20.4 to −18.5) with 10-mg doses, and −20.9% (95% CI, −21.8 to −19.9) with 15-mg doses and −3.1% (95% CI, −4.3 to −1.9) with placebo (P<0.001 for all comparisons with placebo). The percentage of participants who had weight reduction of 5% or more was 85% (95% CI, 82 to 89), 89% (95% CI, 86 to 92), and 91% (95% CI, 88 to 94) with 5 mg, 10 mg, and 15 mg of tirzepatide, respectively, and 35% (95% CI, 30 to 39) with placebo; 50% (95% CI, 46 to 54) and 57% (95% CI, 53 to 61) of participants in the 10-mg and 15-mg groups had a reduction in body weight of 20% or more, as compared with 3% (95% CI, 1 to 5) in the placebo group (P<0.001 for all comparisons with placebo).

Three to 7% of users stopped the drug due to side effects.

Click for a Diabetes Daily article about the drug.

Steve Parker, M.D.

PS: I can help you lose weight without drugs!

And Now For Something Completely Different… Enslaved Icelander Describes Horror of Ottoman Slave Market (1627) 

Adherence to Mediterranean diet linked to  health-related quality of life in children and adolescents

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Nearly all studies demonstrating the healthful effects of the Mediterranean diet were done in adults. Here’s one suggesting benefit in children.

Our findings suggest a positive correlation of Mediterranean diet  adherence with health-related quality of life in children and adolescents. However, future research is needed to strengthen the evidence of this relationship.

Source: Adherence to Mediterranean diet associated with health-related quality of life in children and adolescents: a systematic review | BMC Nutrition | Full Text

     Steve Parker, M.D.

President Biden’s Sept 1, 2022, Speech on “Democracy”

President Biden’s Sept 1, 2022, speech in Philadelphia is likely to have major impact on the November elections. Especially what he says starting at minute 4. “MAGA Republicans do not respect the Constitution, they do not believe in the rule of law…..”

“We must be honest with each other and with ourselves. Too much of what’s happening in our country today is not normal. Donald Trump and the MAGA Republicans represent an extremism that threatens the very foundations of our Republic.”

Three thousand “likes” when I viewed it on YouTube but the “dislike” counter seems to be de-activated. I wonder why. BTW, the U.S. is a constitutional republic, not a democracy.

Iconic

Recipe: Low-Carb Salads

20 recipes from Diet Doctor:

Many people think of salads as boring diet food that will leave you hungry and unsatisfied. But we disagree. Our keto salad recipes are rich in protein — and they’re filled with nutrition, flavors, and healthy fats to keep you fueled all day long.


This is a full meal

I love me a good salad. But check out this link on how to avoid foodborne illness from leafy greens. I got your back.

Steve Parker, M.D.

QOTD: Napoleon on the Bankers

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When a government is dependent on bankers for money, they and not the leaders of government control the situation. Money has no motherland; financiers are without patriotism and without decency; their sole obligation is gain.

  • Napoleon Bonaparte

After I read that, I thought about the US’s Federal Reserve System of banks, the Russia-Ukraine war, the US’s raging inflation problem, the World Economic Forum, Blackrock and Vanguard, income and wealth inequality, recent US shortages of infant formula and tampons, covidiocy, and predictions of basic food shortages and famine. Is it all masterminded by the banksters, to enrich them?

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Steve Parker, M.D.

COVID-19 Link Dump: Vax Causes Myocarditis and Pericarditis, Vax—->Death, Will Docs Ever Admit They Were Wrong?, Dr Malone on Biden’s Treatment With Paxlovid, Novella: Excessive Deaths NOT Caused By the Vax, Vax Safe and Effective?

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From William M. Briggs:

Remember how the woke and super-concerned and awfully caring and, most of all, ignorant (I use this word in its technical sense) censors at YouTube, Twitter and all the rest quashed accounts that said myocarditis was likely a prominent side effect of the mRNA viruses? Which, as we’ll see below, it surely was?

Censoring the unwashed is their natural inclination, yet that happy duty was strengthened by Experts in the bureaucracy whose policy was the Noble Lie. Yes—the “L” word. For do you also remember when CDC Director Rachel Walensky, a physician, announced in her most serious voice, “Vaccinated people don’t carry the virus, don’t get sick.”


From Wayne Allen Root:

33 Dead and Sick Friends From Our Wedding Only 8 Months Ago …all of them vax’d. Anecdotal? Yes, of course. But still….

But it has nothing to do with our wedding. Open your eyes. This is happening everywhere. Non-COVID-19 deaths are up dramatically in the United States (and all over the world). Life insurance companies report non-COVID-19 deaths are up 40% or more among young, working-age Americans. Lincoln National reports death benefit payouts are up over 163% in the year since COVID-19 vaccines came out. These are death increases not seen during World War II.

Read the headlines: Every day a new celebrity, actor, rock star, athlete or CEO is dropping dead “suddenly and unexpectedly.” Most of them are way too young to die or suffer strokes or heart attacks. I’m betting they all have one thing in common: they are VACCINATED.


Steve Kirsch asks:

Will physicians EVER speak out?

Or will they continue to shrug their shoulders and refuse to look at the data showing that these vaccines are the biggest scandal in medical history?

Three young doctors at one Canadian hospital die in same week soon after getting the vax.


Dr Robert Malone on “President” Biden’s treatment with Paxlovid. Listen from 17:55 to 26:20 minutes.


Steven Novella says excessive non-COVID deaths in the U.S. were NOT caused by the vaccines:

These proximate causes likely relate to a few more fundamental causes. For example, delayed or deferred hospital admission or medical care likely resulted in increased deaths from heart disease and stroke. People were simply reluctant to go to the ER for fear of catching COVID there, and because hospitals were overwhelmed. Having experienced the ER during the pandemic I can tell you it was full of a lot of unhappy patients, waiting for beds in overcrowded conditions.

Other deaths are deemed “death of despair”, due to increased alcoholism and drug overdoses. Increase in motor vehicle deaths is interesting, attributed to more fast and reckless driving provoked by relatively empty roads. Increase in homicides was similarly attributed to increases in anxiety and restlessness during the pandemic.

Of course, many of the usual suspects have tried to link excess mortality to vaccines. This has been debunked, however, and in fact the evidence shows a beneficial effect of vaccination on excess mortality.


Another from Steve Kirsch:

The “safe and effective” narrative is falling apart

Here is my list of over 40 leading indicators that the momentum is moving in our favor. I’d be surprised if the narrative doesn’t fall apart soon. It’s now unravelling quickly in the UK.


Steve Parker, M.D.

Weight-Loss Pill Plenity: Does It Work?

“With this raging inflation, I may need to cut back on food and beer.”

Dr Harriet Hall wrote a brief review of the new weight-loss drug Plenity at Science-Based Medicine. Her conclusion:

So far, effectiveness has been shown in only one placebo-controlled trial. Diet and exercise must be continued. It doesn’t work well for everyone: 6 out of 10 users lost at least 5% of their body weight; the other 4 didn’t. It appears to have fewer side effects than other weight loss products. Not a way to achieve ideal weight, but probably worth trying for patients who understand that it is only an aid and not a final solution. I hope they will be encouraged enough by a 22-pound weight loss to continue losing weight with or without Plenity.


Steve Parker, M.D.

PS: Overweight or obese? I can help. No pills or surgery needed.

Recipe: Low-Carb Zuppa Toscana

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DJ Foodie has come up with a low-carb version of zuppa toscana, my wife’s favorite soup at Olive Garden restaurants. We haven’t tried it yet but post a link here for future reference. 9.4 net carbs per 330 calorie serving.

Steve Parker, M.D.