COVID-19: Say Goodbye to Vaccine-Induced Herd Immunity

The various available vaccines likely have different breakthrough infection rates

In Israel, 78% of the population over age 12 is fully vaccinated against COVID-19, with the Pfizer/BioNTech product. Nevertheless, the country his seeing a major surge in cases, particularly the delta variant. This variant is also the dominant one in the U.S. this summer.

Viruses cannot replicate without a living host to provide the cellular hardware for reproduction. With “herd immunity,” the virus can’t find enough hosts within which to replicate. Dr Fauci and other “authorities” are still telling us that once 70-75% of the population is vaccinated, we’ll have herd immunity and the virus will peter out.

Wrong….once again.

Plenty of vaccinated folks in Israel are getting infected (aka breakthrough cases) and spreading the virus to others.

From ScienceMag.org:

What is clear is that “breakthrough” cases are not the rare events the term implies. As of 15 August, 514 Israelis were hospitalized with severe or critical COVID-19, a 31% increase from just 4 days earlier. Of the 514, 59% were fully vaccinated. Of the vaccinated, 87% were 60 or older. “There are so many breakthrough infections that they dominate and most of the hospitalized patients are actually vaccinated,” says Uri Shalit, a bioinformatician at the Israel Institute of Technology (Technion) who has consulted on COVID-19 for the government. “One of the big stories from Israel [is]: ‘Vaccines work, but not well enough.’”

A problem with the Pfizer vaccine is that its protection against severe disease wanes over time. What about vaccine protection against death? Time will tell.

Israel politicians cut a supply deal with Pfizer early-on, and the population jumped on the vaccination bandwagon enthusiastically. At this point many of the vaccinees are over six months out from their original jabs. Pfizer admits that protection drops over time, hence the recommendation for booster shots periodically

Forbes reports that:

Recent data from Israel’s health ministry suggests Pfizer’s Covid-19 vaccine is far less effective at preventing infection and symptomatic illness with the Delta variant than with previous strains of coronavirus, a finding that conflicts with other research indicating high levels of protection against the contagious variant as countries around the world struggle to contain new waves of infection.

A full course of the Pfizer-BioNTech vaccine was just 39% effective at preventing infections and 41% effective at preventing symptomatic infections caused by the Delta Covid-19 variant, according to Israel’s health ministry, down from early estimates of 64% two weeks ago. 

The figures, based on data from an unspecified number of people between June 20 and July 17, are significantly lower than previous estimates of the vaccine’s efficacy against other variants, which initial clinical trials found to be 95%.

I haven’t read much yet about the breakthrough infection rate in those who took the non-Pfizer vaccines, such as Moderna, J&J, and AstraZeneca. I think the latter is not available in the U.S. In Arizona where I live, Pfizer and Moderna dominate the market.

Does natural immunity from infection provide better protection than the vaccines? I’m not sure, but I bet it does. For what it’s worth, I don’t recall seeing a patient with a second COVID-19 infection after having it once. But I’ve treated several patients who failed to be protected by the vaccines.

intubation, mechanical ventilation, ventilator
Head colds rarely lead to intubation

It’s time to face the possibility that we’ll never have great vaccines against COVID-19, just like we don’t have great vaccines against the common cold and the flu. At least the flu vaccines seem to be much safer than the COVID-19 vaccines. COVID-19 may become endemic rather than pandemic, with luck mutating to less virulent variants.

It looks like we’re never getting to herd immunity via the current vaccines. I hope I’m wrong.

Steve Parker, M.D.

PS: Can we skip our flu vaccines this Fall since flu has disappeared?

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YOU Prove You’re Not a Risk to ME!

Not my creation. If this is yours and you don’t want it disseminated, let me know.

You Don’t Have to Lose Muscle as You Age

young woman, exercise, weight training, gym
Not enough weight!

Axel Sigurdsson, MD, PhD, published a great article on prevention of age-related sarcopenia (loss of muscle mass). Click through for details. To stay vigorous as you age, you want to preserve muscle mass and the strength it provides. If you’ve lost muscle mass, you can re-build it. Summary from the good doctor:

Age-related loss of muscle mass (sarcopenia) may start as early as in our thirties and appears to continue for the rest of our lives.

There is also a loss of muscle strength and muscle function. The consequences may often be severe, particularly in the elderly.

Increased physical activity and adequate nutrition are the most powerful tools at our disposal to delay age-related loss of muscle mass.

Well-rounded exercise programs consisting of aerobic and resistance exercises are believed to be most effective.

Modification of dietary habits may be an important tool to prevent the decline in muscle mass and function that occurs with aging.

Adequate protein intake is of key importance. Animal-derived protein may provide a higher and broader biological value than vegetable protein.

Fish consumption is recommended and fruits and vegetables should be consumed regularly.

Nutritional supplements containing essential amino acids may be helpful. This is particularly true for whey protein.

Fish-derived protein hydrolysates also appear promising.

Pro Tip: Hold your fish in front of your body with outstretched arms to make it look bigger!

Adequate intake of vitamin D is essential.

“Fish-derived protein hydrolysates” doesn’t sound very appetizing. I’ll stick with real fish for now, especially cold-water fatty fish.

Steve Parker, M.D.

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Mediterranean Diet May Prevent Cancer Only In Women, Not Men

The traditional Mediterranean diet has long been linked to lower risk of certain cancers, particularly colon, breast, uterus, and prostate cancer. That’s one reason the diet is usually ranked as the #1 healthiest diet in the U.S. News and World Report’s annual diet survey. A 2020study of a Netherlands population suggest that the anti-cancer benefit applies only to women. Excerpts from the Journal of the Academy of Nutrition and Dietetics:

“In this NLCS analysis, sex-specific associations of a priori defined Mediterranean diet adherence with risks of overall cancer and cancer subgroups defined by relations with 3 major cancer risk factors (tobacco smoking, obesity, and alcohol consumption) were investigated. In women, middle compared with low aMEDr values [alternate Mediterranean diet score without alcohol] were significantly associated with a reduced risk of overall cancer and the majority of the cancer subgroups investigated. Other associations in women were not statistically significant after full adjustment for confounding, but all estimates were below 1. No association was observed between aMEDr and risk of overall cancer or any of the cancer subgroups in men. Inclusion of alcohol in the Mediterranean diet score diminished the model performance.

“Even though the association of Mediterranean diet adherence with overall cancer risk is comprised of a combination of potentially diverging associations with individual cancer (sub)types, overall cancer risk is an interesting end point for epidemiological studies. It provides insight in the overall possible benefits of Mediterranean diet adherence and the potential of the Mediterranean diet as a dietary strategy for cancer prevention. Findings of previously conducted prospective studies evaluating the relation between a priori defined Mediterranean diet adherence and overall cancer risk have been inconclusive and were rarely specified by sex.

“A priori defined Mediterranean diet adherence has previously significantly been associated with a reduced overall cancer risk in the total European Prospective Investigation into Cancer and Nutrition (EPIC) cohort as well as the Greek EPIC cohort.9,10 Comparing the highest with the lowest Mediterranean diet adherence category in the total EPIC cohort, HRs (95% CIs) of 0.93 (0.88-0.99) and 0.93 (0.89-0.96) were observed for men and women, respectively. Although inverse associations were also suggested for both sexes in the Greek EPIC cohort, only effect estimates obtained in women reached statistical significance (HRhigh vs low [95% CI]: 0.83 [0.63-1.09] for men and 0.73 [0.56-0.96] for women). In addition to the previously mentioned EPIC studies, weak inverse associations between Mediterranean diet adherence and overall cancer risk were observed in men (HRper tertile increase [95% CI]: 0.97 [0.94-1.01]) and women (HRper tertile increase [95% CI]: 0.97 [0.93-1.00]) participating in the Swedish prospective Västerbotten Intervention Programme. In the present analysis of the NLCS cohort, a priori defined Mediterranean diet adherence was not associated with overall cancer risk in men. In regard to women, although the multivariable-adjusted associations in female NLCS participants were not statistically significant in most cases, effect estimates were stronger inverse than those observed for women in the total EPIC cohort, which did reach statistical significance possibly due to the larger number of cases. Additional cohort studies in Germany and France have investigated the association between Mediterranean diet adherence and overall cancer risk in men and women together and did not observe an association. Besides the prospective cohort evidence, a reduced overall cancer risk (borderline significant, P = .05) was indicated in patients with coronary heart disease who followed an α-linolenic acid-rich Mediterranean-type diet as opposed to a control diet close to the step 1 prudent diet of the American Heart Association in the randomized Lyon Diet Heart Study. However, results should be interpreted with caution because they were based on only 24 incident cancer cases.”

Source: Adherence to the Mediterranean Diet and Overall Cancer Incidence: The Netherlands Cohort Study – Journal of the Academy of Nutrition and Dietetics

At least we still have unequivocal evidence for the cardiovascular, longevity, and anti-dementia properties of the Mediterranean diet. Or do we?

Steve Parker, M.D.

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Mediterranean Diet May Help Men With Prostate Cancer

Grapes are a time-honored component of the Mediterranean diet

The traditional Mediterranean diet lowers the risk of several cancers, one of which is prostate cancer. Now we have evidence that the diet can help prevent progression of early-stage prostate cancer.

In a study to examine a Mediterranean diet in relation to prostate cancer progression in men on active surveillance, researchers from The University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease.

Source: Mediterranean Diet May Help Men With Prostate Cancer

Steve Parker, M.D.

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QOTD: Wesbury and Stein on Capitalism Versus Socialism

After capitalism

…it’s not possible to analyze the economy these days without focusing heavily on what government is doing.  Between the Federal Reserve, fiscal policy, and COVID-related restrictions, little in our lives avoids governmental influences.

…Certainly government has grown, in sheer size, and also in power.  When the CDC, a health agency, can impose a moratorium on evictions (in violation of property-owners rights), the U.S. has moved a long way from its historic roots.  If, after passing $5 trillion in emergency pandemic spending, the government can be talking about $4.5 trillion more, we have entered new territory.

The history of the world has been a battle between two competing ideologies of how resources should be distributed: Capitalism and Socialism.

Capitalism distributes resources to the most productive use through markets and competition, while at the same time putting brakes on greed and selfishness.  In order to accumulate resources in a capitalist system, you must provide goods or services for which someone else is willing to pay.  If your cost of production is greater than what the market is willing to pay, you will not create much wealth.  Or, if a competitor can provide the equivalent or better for a lower price, you will lose market share and therefore your wealth.

As a result, while it may be true that some people in a capitalist system become extremely wealthy, they do it by creating goods or services that people want and in a way that competitors have a difficult time copying.

Under Socialism, on the other hand, politicians distribute resources.  They tax individuals who have been able to create income and wealth and then transfer those resources to their favored causes or group, often while shutting down competition.  Governments do not create wealth, they spend it.

Brian Wesbury and Robert Stein

Science-Based Osteoarthritis Treatment Guidelines

Voltaren is over-the-counter in the U.S.

Here’s a link to a long, boring scientific article on the non-surgical treatment of knee, hip, and multiple-joint osteoarthritis, aka degenerative joint disease (DJD).

My main reason for posting this is that I thought that topical capsaicin cream was proven as effecting in relieving pain. According to the article a hand, it is not. The authors don’t recommend it. It may work for some folks. BTW, do not let any of it get into your eye like I did! Wash your hands well after use.

I tried it anyway

From my reading elsewhere (link to NEJM), topical NSAIDs are recommended over systemic use. NSAID = non-steroidal anti-inflammatory drug. I picked up a tube of Voltaren (diclofenac) recently to try on my knee. I must say I was disappointed to read on the box that application four times daily for a couple weeks may be necessary before you feel relief. That seemed like too much hassle so I didn’t give it a fair trial. Guess I wasn’t hurting enough. I diagnosed my acute pain later as pes anserinus pain syndrome anyway, not DJD.

Steve Parker, M.D.

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Despite World’s Highest Vax Rate, CDC Recommends Avoiding Travel to Gibralter

Not the Rock of….

Gibralter is pandemic-famous for being the first nation to vaccinate its entire adult population. The effort only took nine weeks and was completed in March 2021. Gibralter has only 34,000 inhabitants in its 2.6 square miles.

So Gibralter should be wide open an back to normal life now, right?

Guess again.

A couple weeks ago, the CDC added Gibralter to its “very high COVID-19 risk” list. CDC recommends not traveling to countries on the list. The linked article at WDSU.com notes that:

Destinations that fall into the “very high” risk category have had more than 500 cases per 100,000 residents in the past 28 days, according to CDC parameters.

These vaccines are increasingly looking like a pig in a poke.

Steve Parker, M.D.

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COVID-19 Delta Variant on the Rise in Iceland Despite Incredibly High Vaccination Rate

The various available vaccines likely have different adverse effect and efficacy profiles

From News.com.au on August 10, 2021:

Some 96 per cent of all Icelandic women over 16 have received at least one vaccine dose. The figure for men is about 90 per cent.

In total, 86 per cent of the population has been fully vaccinated. 

It is an outstanding result – so much so, the Reykjavík government felt they had this pandemic beaten.

In June, they rolled back social distancing, mask and travel restrictions.

But those restrictions have been reimposed as a Covid-19 Delta outbreak has sent case numbers soaring.

And even with a significantly reduced rate of severe illness, the explosive outbreak is seriously straining the tiny nation’s health system.

I was vaccinated against tetanus, polio, rubella, whooping cough, and measles: and I never came down with any of those infections. Not even mild forms of them.

It’s starting to look like the COVID-19 vaccines aren’t all they were promised to be.

Steve Parker, M.D.

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QOTD: C.S. Lewis on Omnipotent Moral Busybodies

Of all tyrannies, a tyranny sincerely exercised for the good of its victims may be the most oppressive. It would be better to live under robber barons than under omnipotent moral busybodies. The robber baron’s cruelty may sometimes sleep, his cupidity may at some point be satiated; but those who torment us for our own good will torment us without end for they do so with the approval of their own conscience. They may be more likely to go to Heaven yet at the same time likelier to make a Hell of earth. This very kindness stings with intolerable insult. To be “cured” against one’s will and cured of states which we may not regard as disease is to be put on a level of those who have not yet reached the age of reason or those who never will; to be classed with infants, imbeciles, and domestic animals.

h/t Bayou Renaissance Man